Role of ST2 in Acute Pancreatitis
Acute pancreatitis is characterized by an inflammatory storm which regulatory pathways are not well known. The IL-1 cytokine family is activated early during acute pancreatitis and secretion of alarmins is speculated during pancreatic necrosis. IL-33 is a member of the IL-1 family, it can act as an alarmin and its receptor, ST2, is known to sequester MyD88 which might regulate the acute pancreatitis inflammatory storm. The aim of this study is to investigate ST2 pathway in human acute pancreatitis and in murine experimental models of acute pancreatitis.
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Study of ST2-IL-33 Pathway in Acute Pancreatitis|
- Concentration of soluble ST2 in serum [ Time Frame: Within 30 days after onset of acute pancreatitis ] [ Designated as safety issue: No ]Concentration of soluble ST2 will be assessed in the serum of patient with an episode of acute pancreatitis, on the day of admission to the hospital as well as 24h, 48h, 7 days and 30 days later.
|Study Start Date:||January 2005|
|Estimated Study Completion Date:||September 2008|
|Primary Completion Date:||September 2008 (Final data collection date for primary outcome measure)|
Patients admitted in our institution for an episode of acute pancreatitis