Effects of Joint Effusion on Quadriceps Muscle

This study has been completed.
Sponsor:
Information provided by:
The Catholic University of Korea
ClinicalTrials.gov Identifier:
NCT01314820
First received: March 14, 2011
Last updated: NA
Last verified: January 2010
History: No changes posted
  Purpose

The present study investigated whether the presence of fluid in the joint affected peak torque and the root mean square (RMS) values of surface electromyography (EMG) in patients symptomatic for osteoarthritis (OA).


Condition Intervention
Knee Osteoarthritis
Other: normal saline injection
Other: sham injection

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Investigator)
Primary Purpose: Basic Science
Official Title: Effects of Joint Effusion on Quadriceps Muscle in Patients With Knee Osteoarthritis

Resource links provided by NLM:


Further study details as provided by The Catholic University of Korea:

Primary Outcome Measures:
  • the peak torque of the knee extensors [ Time Frame: within 5 minutes after intervention ] [ Designated as safety issue: No ]
    to evaluate the effect of effusion on the peak torque of the knee extensors


Secondary Outcome Measures:
  • the root mean square values of the vastus medialis and vastus lateralis muscles [ Time Frame: within 5 minutes after intervention ] [ Designated as safety issue: No ]
    to evaluate the effect of effusion on the RMS of the vastus medialis (VM) and vastus lateralis (VL) muscles


Enrollment: 40
Study Start Date: June 2009
Study Completion Date: June 2010
Primary Completion Date: January 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: normal saline injection
20 cc normal saline injection into the knee joint
Other: normal saline injection
20 cc normal saline injection into knee joint
Other Name: normal saline
Sham Comparator: sham injection
knee injection without saline
Other: sham injection
no saline injection
Other Name: no normal saline

Detailed Description:

Several studies have shown that knee effusion influenced quadriceps muscle activity and induced quadriceps arthrogenic muscle inhibition in normal volunteers. However, the effect of joint effusion on the quadriceps of patients with OA is controversial,and few patients with OA have been included in studies of joint effusion.

  Eligibility

Ages Eligible for Study:   50 Years to 75 Years
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • 50 years old or older with knee osteoarthritis
  • knee pain without joint effusion confirmed by ultrasonography

Exclusion Criteria:

  • the presence of knee joint effusion determined using US
  • a history of knee injury or surgery
  • a history of knee injection within 3 months
  • a history of inflammatory arthritis
  • taking anticoagulants
  • balance or gait disturbance
  • diabetes mellitus
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01314820

Locations
Korea, Republic of
Department of Rehabilitation Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea
Seoul, Korea, Republic of, 137-701
Sponsors and Collaborators
The Catholic University of Korea
Investigators
Study Director: Jongin Lee, M.D Department of Rehabilitation Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea
  More Information

Publications:
Responsible Party: Department of Rehabilitation Medicine, Seoul St. Mary's Hospital,, College of Medicine, The Catholic University of Korea
ClinicalTrials.gov Identifier: NCT01314820     History of Changes
Other Study ID Numbers: KC09OISI0161
Study First Received: March 14, 2011
Last Updated: March 14, 2011
Health Authority: Korea: Institutional Review Board

Keywords provided by The Catholic University of Korea:
Knee
Osteoarthritis
Effusion.

Additional relevant MeSH terms:
Osteoarthritis
Osteoarthritis, Knee
Hydrarthrosis
Arthritis
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases

ClinicalTrials.gov processed this record on October 19, 2014