Advanced Imaging for Glaucoma Study (AIGS)

The study will enroll both males and females and include all ethnic and racial groups through clinical practices in the centers. The study will enroll subjects in the older adult age range commonly affected by glaucoma - 40 years or older. The study will exclude people with life-threatening or debilitating illness that would make 5-year participation unlikely or cooperation with tests difficult. For similar reasons those older than 79 years are excluded. The study also excludes those with any disease that might confound the diagnosis of glaucoma. Otherwise people with any health status are eligible for enrollment. Three groups of participants are recruited in the AIG study: normal (N), glaucoma suspects & preperimetric glaucoma (GSPPG) and perimetric glaucoma (PG).

Inclusion Criteria for Normal Participants:

• No history of glaucoma, retinal pathology, keratorefractive surgery, or corticosteroid use.
• Normal visual field (VF), intraocular pressure (IOP), optic nerve head and nerve fiber layer.
• Central pachymetry > 500 μm.
• Open angle.

Inclusion Criteria for Glaucoma Suspects & Pre-Perimetric Glaucoma Participants:

• Ocular hypertension, defined as IOP ≥ 24 mmHg in one eye and IOP ≥ 22 mmHg in the fellow eye, on or off glaucoma medications.
• Optic nerve head (ONH) or nerve fiber layer (NFL) defect visible on slit-lamp biomicroscopy and stereo color fundus photography as defined for the PG group.
• The fellow eye meeting the eligibility criteria for the PG group.
• GSPPG eyes must not have an abnormal VF as defined for the PG group.
• GSPPG participants having glaucomatous ONH or NFL defect are subclassified as PPG; the remainder are subclassified as GS.

Inclusion Criteria for Perimetric Glaucoma Participants:

• Abnormal VF and
• Glaucomatous ONH of NFL defect.

Exclusion Criteria Common to All Groups:

• Best corrected visual acuity worse than 20/40.
• Age < 40 or > 79 years.
• Refractive error > +3.0D or < -7.0 D.
• Previous intraocular surgery except for uncomplicated cataract extraction with posterior chamber IOL implantation.
• Diabetic retinopathy or other disease that may cause visual field loss or optic disc abnormalities.
• Inability to clinically view or photograph the optic discs due to media opacity or poorly dilating pupil.
• Inability to obtain advanced imaging data with acceptable quality or reliable VF test results.
• Life-threatening or debilitating illness making it unlikely patient could successfully complete the study.
• Refusal of informed consent or of commitment to the full length of the study.