Unknown Glucose Metabolism Disorders In Patients With Coronary Artery Disease
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Purpose
This study aimed to examine the prevalence of glucose metabolism disorders (GMD)in the patients with coronary artery disease and the relationship between different GMDs and coronary artery disease (CAD).
| Condition | Intervention |
|---|---|
|
Diabetes Mellitus |
Other: ogtt for patients with coronary artery disease |
| Study Type: | Observational |
| Study Design: | Observational Model: Case Control Time Perspective: Prospective |
| Official Title: | The Relationship Between Previously Unknown Glucose Metabolism Disorders and Coronary Artery Disease in Patients Suffering From Coronary Artery Disease |
- Frequency of unknown glucose metabolism disorders in patients with coronary artery disease [ Time Frame: 1 year ] [ Designated as safety issue: Yes ]Results: While GMDs were detected in 58.26% (n=134 patients) of CAD patients, 41.74% of them (n=96 patients) were found to have normal glucose metabolism.
- Fasting and 120 minute glucose levels have relation with vessels' stenosis. [ Time Frame: 1 year ] [ Designated as safety issue: Yes ]Fasting glucose level was found to have a significant correlation with the total number of stenotic coronary vessels (p=0.0001) and the stenosis rate of all vessels . OGTT 120-minute glucose levels were found to have a significant correlation with the total number of stenotic coronary vessels and the stenosis rate of vessels with the exception of LAD.
| Enrollment: | 230 |
| Study Start Date: | June 2009 |
| Study Completion Date: | June 2010 |
| Primary Completion Date: | June 2010 (Final data collection date for primary outcome measure) |
| Groups/Cohorts | Assigned Interventions |
|---|---|
|
coronary artery disease
patients with coronary artery disease
|
Other: ogtt for patients with coronary artery disease
75 g OGTT
Other Name: no name
|
Detailed Description:
Context: There are more than 220 million people diagnosed with diabetes mellitus (DM) in the world. DM is a serious risk factor for coronary artery disease (CAD). This study aimed to examine the prevalence of glucose metabolism disorders (GMD) in te patients with coronary artery disease and the relationship between different GMDs and CAD.
Settings: 230 patients with coronary artery disease and without any known GMDs were included the study. Coronary angiography was used to diagnose CAD. Patients were administered the 75 g Oral Glucose Tolerance Test (OGTT).
Eligibility| Ages Eligible for Study: | 30 Years to 70 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Probability Sample |
patients with coronary artery disease and who had no glucose metabolism disorders.
Inclusion Criteria:
- Patients with coronary artery disease and who had no glucose metabolism disorders were included to study.
Exclusion Criteria:
- Patients who had previous GMDs, malignancies, chronic liver and kidney diseases, rheumatologic disorders, and a BMI higher than 35 kg/m2 were excluded from the study.
Contacts and Locations More Information
No publications provided
| Responsible Party: | Gulhane School of Medicine, Dep. of Endocrinology and Metabolism |
| ClinicalTrials.gov Identifier: | NCT01310556 History of Changes |
| Other Study ID Numbers: | 12.05.2009-131-1068 |
| Study First Received: | March 7, 2011 |
| Last Updated: | June 17, 2011 |
| Health Authority: | Turkey: Ministry of Health |
Keywords provided by Gulhane School of Medicine:
|
OGTT coronary artery disease |
Additional relevant MeSH terms:
|
Coronary Artery Disease Myocardial Ischemia Coronary Disease Diabetes Mellitus Metabolic Diseases Glucose Metabolism Disorders |
Heart Diseases Cardiovascular Diseases Arteriosclerosis Arterial Occlusive Diseases Vascular Diseases Endocrine System Diseases |
ClinicalTrials.gov processed this record on June 18, 2013