Study to Evaluate the Safety and Efficacy of a Single Tablet Regimen of Emtricitabine/Rilpivirine/Tenofovir Disoproxil Fumarate Compared With a Single Tablet Regimen of Efavirenz/Emtricitabine/Tenofovir Disoproxil Fumarate in HIV-1 Infected, Antiretroviral Treatment-Naïve Adults.

Inclusion Criteria:

• Ability to understand and sign a written informed consent form.
• Plasma HIV 1 RNA levels ≥ 2,500 copies/mL at screening.
• No prior use of any approved or experimental anti-HIV drug for any length of time with the exception of PrEP (pre-exposure prophylaxis).
• No use of Truvada or Viread for pre-exposure prophylaxis (PrEP) within 30 days of screening.
• Screening genotype report showing sensitivity to EFV, FTC, TDF, and lack of the RPV mutations.
• Normal ECG.
• Hepatic transaminases (AST and ALT) ≤ 5 x upper limit of normal (ULN).
• Total bilirubin ≤ 1.5 mg/dL, or normal direct bilirubin.
• Adequate hematologic function.
• Serum amylase ≤ 5 x ULN (subjects with serum amylase > 5 x ULN will remain eligible if serum lipase is ≤ 5 x ULN).
• Adequate renal function.
• Males and Females of childbearing potential must agree to utilize highly effective contraception methods (two separate forms of contraception, one of which must be an effective barrier method, or be non-heterosexually active, practice sexual abstinence or have a vasectomized partner) from screening throughout the duration of study period and for 12 weeks following the last dose of study drug.
• Adult (≥ 18 years) males or non-pregnant females.
• Life expectancy ≥ 1 year.

Exclusion Criteria:

• A new AIDS defining condition diagnosed within the 30 days prior to screening with the exception of CD4 count and percentage.
• Females who are breastfeeding.
• Positive serum pregnancy test (female of childbearing potential).
• Proven or suspected acute hepatitis in the 30 days prior to study entry.
• Subjects receiving drug treatment for Hepatitis C, or subjects who are anticipated to receive treatment for Hepatitis C during the course of the study.
• Subjects experiencing decompensated cirrhosis.
• Have an implanted defibrillator or pacemaker.
• Current alcohol or substance abuse.
• A history of malignancy within the past 5 years or ongoing malignancy other than cutaneous Kaposi's sarcoma, basal cell carcinoma, or resected, non-invasive cutaneous squamous carcinoma.
• Active, serious infections requiring parenteral antibiotic or antifungal therapy within 30 days prior to Baseline.
• Receiving ongoing therapy or anticipated to need to initiate drugs or herbal/natural supplements during the study that are contraindicated or not recommended for use, including drugs not to be used with FTC, EFV, RPV, TDF, and Atripla®; or subjects with known allergies to the excipients of the FTC/RPV/TDF single tablet regimen and/or Atripla® tablets.