Formulations of Liposomal Local Anesthetics
This blinded cross-over study aim to evaluate the efficacy of liposome-encapsulated ropivacaine formulation for dental anesthesia.
Underdosing of Local Anesthetics, Initial Encounter
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Double Blind (Subject, Investigator, Outcomes Assessor)
Primary Purpose: Health Services Research
|Official Title:||Formulations of Liposomal Local Anesthetics for Dental Anesthesia|
- After anesthetic injection the pulpal response was assessed by an electrical pulp tester. [ Time Frame: 100 minutes ] [ Designated as safety issue: No ]
- Duration of soft tissue anesthesia was measured as the time from beginning to end of lip and gingival numbness. [ Time Frame: 240 minutes ] [ Designated as safety issue: No ]
|Study Start Date:||February 2007|
|Study Completion Date:||June 2007|
|Primary Completion Date:||May 2007 (Final data collection date for primary outcome measure)|
Experimental: Anesthetic efficacy
Local anesthetics were injected at the apex of the maxillary right canine.
1,8 mL of the local anesthetic formulations were injected at the apex of the maxillary right canine.
This blinded cross-over study aim to evaluate the efficacy of liposome-encapsulated 0, 5% ropivacaine for dental anesthesia after maxillary infiltration.
|Piracicaba Dental School|
|Piracicaba, São Paulo, Brazil|
|Principal Investigator:||Michelle Franz-Montan, PhD||Researcher at Unicamp|