Effect of Remote Ischemic Preconditioning on Lung Injury After Pulmonary Lobectomy
This study has been completed.
Sponsor:
Cai Li
Information provided by (Responsible Party):
Cai Li, First Affiliated Hospital, Sun Yat-Sen University
ClinicalTrials.gov Identifier:
NCT01307085
First received: March 1, 2011
Last updated: October 7, 2012
Last verified: October 2012
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Purpose
The purpose of this study is to determine whether ischemic preconditioning reduces lung injury in patients undergoing pulmonary lobectomy.
| Condition | Intervention |
|---|---|
|
Lung Neoplasms |
Procedure: remote ischemic preconditioning |
| Study Type: | Interventional |
| Study Design: | Allocation: Randomized Endpoint Classification: Safety/Efficacy Study Intervention Model: Parallel Assignment Masking: Double Blind (Investigator, Outcomes Assessor) Primary Purpose: Prevention |
| Official Title: | Effect of Remote Ischemic Preconditioning on Lung Injury in Patients Undergoing Pulmonary Lobectomy:a Randomised Controlled Trial |
Resource links provided by NLM:
Further study details as provided by First Affiliated Hospital, Sun Yat-Sen University:
Primary Outcome Measures:
- Limb remote ischemic preconditioning has effective protection of lung injury in patients undergoing pulmonary lobectomy [ Time Frame: Jan,2012 ] [ Designated as safety issue: Yes ]Compared with the control group, patients in the LRIP group had significantly higher Cs and Cd , along with lower PA-aDO2 and RI at various phase (P<0.05). Serum concentration of IL-6,IL-8, TNF-ɑ and MDA in LRIP group were decreased significantly at postoperative time points compared with those in control group (P<0.05), but SOD was increased significantly at the same time (P<0.05).
| Enrollment: | 74 |
| Study Start Date: | February 2011 |
| Study Completion Date: | September 2012 |
| Primary Completion Date: | September 2012 (Final data collection date for primary outcome measure) |
| Arms | Assigned Interventions |
|---|---|
|
Experimental: preconditioning
Adult patients undergoing elective pulmonary lobectomy were received a remote ischemic preconditioning group after induction of anaesthesia.
|
Procedure: remote ischemic preconditioning
Remote ischaemic preconditioning consisted of three 5-min cycles of right upper limb ischaemia, induced by an automated cuff-inflator placed on the upper arm and inflated to 200 mm Hg, with an intervening 5 min of reperfusion during which the cuff was deflated.
Other Name: RIP
|
|
No Intervention: conventional
Adult patients undergoing pulmonary lobectomy were received no treatment after induction of anaesthesia.
|
Detailed Description:
Remote ischemic preconditioning is an intervention in which brief ischemia of one tissue or organ protects remote organs from a sustained episode of ischemia. It is known that one-lung ventilation in patients undergoing pulmonary lobectomy, which may cause acute lung injury. The investigators did a single-blinded randomised controlled study to establish whether remote ischemic preconditioning reduces lung injury in these patients.
Eligibility| Ages Eligible for Study: | 20 Years to 65 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
Criteria
Inclusion Criteria:
- Clinical diagnosis of pulmonary carcinoma
- Must be received pulmonary lobectomy
Exclusion Criteria:
- Restrictive ventilatory disorder
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01307085
Locations
| China, Guangdong | |
| Departmeng of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University | |
| GuangZhou, Guangdong, China, 510080 | |
Sponsors and Collaborators
Cai Li
Investigators
| Principal Investigator: | Xuan Ke Liu, Ph.d | Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University |
More Information
No publications provided
| Responsible Party: | Cai Li, Department of Anesthesiology, First Affiliated Hospital, Sun Yat-Sen University, First Affiliated Hospital, Sun Yat-Sen University |
| ClinicalTrials.gov Identifier: | NCT01307085 History of Changes |
| Other Study ID Numbers: | RIP1126 |
| Study First Received: | March 1, 2011 |
| Last Updated: | October 7, 2012 |
| Health Authority: | China: Ethics Committee |
Keywords provided by First Affiliated Hospital, Sun Yat-Sen University:
|
remote ischemic preconditioning lung injury pulmonary lobectomy |
Additional relevant MeSH terms:
|
Neoplasms Lung Neoplasms Lung Injury Respiratory Tract Neoplasms Thoracic Neoplasms |
Neoplasms by Site Lung Diseases Respiratory Tract Diseases Thoracic Injuries Wounds and Injuries |
ClinicalTrials.gov processed this record on May 23, 2013