Branched-chain Amino Acids Supplementation and Resistance Exercise-induced Muscle Damage and Inflammation

This study has suspended participant recruitment.
Sponsor:
Information provided by:
University of Sao Paulo
ClinicalTrials.gov Identifier:
NCT01305018
First received: February 25, 2011
Last updated: May 4, 2011
Last verified: April 2011
  Purpose

This study aims to evaluate the effects of branched-chain amino acids (BCAA) supplementation on resistance exercise-induced muscle damage and inflammation.


Condition Intervention
Muscle Damage
Inflammation
Dietary Supplement: BCAA
Dietary Supplement: Leucine
Dietary Supplement: Placebo

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Treatment
Official Title: Effects of Leucine and Branched-chain Amino Acids (BCAA) Supplementation on Resistance Exercise-induced Muscle Damage and Inflammation: a Randomized, Double-blind, and Placebo-controlled Study

Resource links provided by NLM:


Further study details as provided by University of Sao Paulo:

Primary Outcome Measures:
  • Muscle maximal strength [ Time Frame: 4 days ] [ Designated as safety issue: Yes ]
  • Muscle edema [ Time Frame: 4 days ] [ Designated as safety issue: Yes ]
  • Muscle soreness [ Time Frame: 4 days ] [ Designated as safety issue: Yes ]

Secondary Outcome Measures:
  • Muscle inflammation [ Time Frame: 4 days ] [ Designated as safety issue: Yes ]
    Immunohistochemistry, protein expression.

  • Muscle damage [ Time Frame: 4 days ] [ Designated as safety issue: Yes ]
    Serum creatine kinase


Estimated Enrollment: 30
Study Start Date: August 2011
Estimated Study Completion Date: August 2012
Estimated Primary Completion Date: January 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Exercise and BCAA Dietary Supplement: BCAA
7 g of leucine + 3,5 g of isoleucine + 3,5 g of valine per day during 9 days
Experimental: Exercise and Leucine Dietary Supplement: Leucine
7 g of leucine + 7 g of alanine per day during 9 days
Placebo Comparator: Exercise and Placebo Dietary Supplement: Placebo
14 g of alanine per day during 9 days

  Eligibility

Ages Eligible for Study:   18 Years to 30 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Sedentary;
  • No muscle disorders;
  • Must be able to swallow tablets
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01305018

Locations
Brazil
University of São Paulo - School of Physical Education and Sports
São Paulo, Brazil, 05508-030
Sponsors and Collaborators
University of Sao Paulo
  More Information

No publications provided

Responsible Party: Claudia Ribeiro da Luz, University of São Paulo
ClinicalTrials.gov Identifier: NCT01305018     History of Changes
Other Study ID Numbers: 071287
Study First Received: February 25, 2011
Last Updated: May 4, 2011
Health Authority: Brazil: Ethics Committee

Keywords provided by University of Sao Paulo:
Branched-chain amino acids
Leucine
Muscle damage
Inflammation
supplementation
resistance exercise-induced

Additional relevant MeSH terms:
Inflammation
Pathologic Processes

ClinicalTrials.gov processed this record on July 28, 2014