Branched-chain Amino Acids Supplementation and Resistance Exercise-induced Muscle Damage and Inflammation

This study has suspended participant recruitment.
Sponsor:
Information provided by:
University of Sao Paulo
ClinicalTrials.gov Identifier:
NCT01305018
First received: February 25, 2011
Last updated: May 4, 2011
Last verified: April 2011
  Purpose

This study aims to evaluate the effects of branched-chain amino acids (BCAA) supplementation on resistance exercise-induced muscle damage and inflammation.


Condition Intervention
Muscle Damage
Inflammation
Dietary Supplement: BCAA
Dietary Supplement: Leucine
Dietary Supplement: Placebo

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Treatment
Official Title: Effects of Leucine and Branched-chain Amino Acids (BCAA) Supplementation on Resistance Exercise-induced Muscle Damage and Inflammation: a Randomized, Double-blind, and Placebo-controlled Study

Resource links provided by NLM:


Further study details as provided by University of Sao Paulo:

Primary Outcome Measures:
  • Muscle maximal strength [ Time Frame: 4 days ] [ Designated as safety issue: Yes ]
  • Muscle edema [ Time Frame: 4 days ] [ Designated as safety issue: Yes ]
  • Muscle soreness [ Time Frame: 4 days ] [ Designated as safety issue: Yes ]

Secondary Outcome Measures:
  • Muscle inflammation [ Time Frame: 4 days ] [ Designated as safety issue: Yes ]
    Immunohistochemistry, protein expression.

  • Muscle damage [ Time Frame: 4 days ] [ Designated as safety issue: Yes ]
    Serum creatine kinase


Estimated Enrollment: 30
Study Start Date: August 2011
Estimated Study Completion Date: August 2012
Estimated Primary Completion Date: January 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Exercise and BCAA Dietary Supplement: BCAA
7 g of leucine + 3,5 g of isoleucine + 3,5 g of valine per day during 9 days
Experimental: Exercise and Leucine Dietary Supplement: Leucine
7 g of leucine + 7 g of alanine per day during 9 days
Placebo Comparator: Exercise and Placebo Dietary Supplement: Placebo
14 g of alanine per day during 9 days

  Eligibility

Ages Eligible for Study:   18 Years to 30 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Sedentary;
  • No muscle disorders;
  • Must be able to swallow tablets
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01305018

Locations
Brazil
University of São Paulo - School of Physical Education and Sports
São Paulo, Brazil, 05508-030
Sponsors and Collaborators
University of Sao Paulo
  More Information

No publications provided

Responsible Party: Claudia Ribeiro da Luz, University of São Paulo
ClinicalTrials.gov Identifier: NCT01305018     History of Changes
Other Study ID Numbers: 071287
Study First Received: February 25, 2011
Last Updated: May 4, 2011
Health Authority: Brazil: Ethics Committee

Keywords provided by University of Sao Paulo:
Branched-chain amino acids
Leucine
Muscle damage
Inflammation
supplementation
resistance exercise-induced

Additional relevant MeSH terms:
Inflammation
Pathologic Processes

ClinicalTrials.gov processed this record on April 14, 2014