Association of Circulating Chemerin Levels and Arterial Stiffness

The recruitment status of this study is unknown because the information has not been verified recently.
Verified January 2011 by Korea University.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Korea University
ClinicalTrials.gov Identifier:
NCT01293929
First received: February 10, 2011
Last updated: March 3, 2011
Last verified: January 2011
  Purpose

Chemerin is a novel adipokine that might provide a link between chronic inflammation and obesity. Pulse wave velocity(PWV) is a useful method for examining arterial stiffness, meaning early-stage atherosclerosis. Therefore, in the present study, the investigators examined the relationship between circulating chemerin and arterial stiffness measured using PWV in obese persons.


Condition
Obesity
Atherosclerosis

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional

Resource links provided by NLM:


Further study details as provided by Korea University:

Primary Outcome Measures:
  • The difference of serum chemerin level between obese and non-obese groups [ Time Frame: at the time of initial enrollment (4weeks) ] [ Designated as safety issue: No ]
    serum chemerin levels of all participants were by determined by an enzyme-linked immunosorbent assay (ELISA) kit (Biovender Laboratory Medicine Inc., Modrice, Czech Republic)


Secondary Outcome Measures:
  • The correlation of serum chemerin levels with arterial stiffness [ Time Frame: at the time of enrollment (4 weeks) ] [ Designated as safety issue: No ]
    Arterial stiffness was measure using a Colin Waveform Analyser (model BP-203RPE II; Colin, Komaki, Japan). It was expressed as branchial ankle pulswe wave velocity (baPWV)


Estimated Enrollment: 120
Study Start Date: February 2011
Estimated Study Completion Date: March 2011
Estimated Primary Completion Date: March 2011 (Final data collection date for primary outcome measure)
Groups/Cohorts
Non- obese group
Obese group

  Eligibility

Ages Eligible for Study:   20 Years to 80 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Obese and age, gender matched non-obese group who underwent a medical health check in the Korea University Guro hospital

Criteria

Inclusion Criteria:

  • Self referred persons for visiting routine medical check in our clinic

Exclusion Criteria:

  • Malignancy
  • Severe renal or hepatic disease
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01293929

Contacts
Contact: Hye Jin Yoo 82226263045 deisy21@naver.com

Locations
Korea, Republic of
Hye Jin Yoo Recruiting
Seoul, Korea, Republic of
Contact: Hye Jin Yoo    82226263045    deisy21@naver.com   
Sponsors and Collaborators
Korea University
  More Information

No publications provided

Responsible Party: Hye Jin Yoo, Korea university
ClinicalTrials.gov Identifier: NCT01293929     History of Changes
Other Study ID Numbers: A102065-1011-1070100
Study First Received: February 10, 2011
Last Updated: March 3, 2011
Health Authority: South Korea: Institutional Review Board

Additional relevant MeSH terms:
Atherosclerosis
Arteriosclerosis
Arterial Occlusive Diseases
Vascular Diseases
Cardiovascular Diseases

ClinicalTrials.gov processed this record on September 22, 2014