Ability of Near Infrared Spectroscopy to Isolate Compartments of the Extremity
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Purpose
Near infrared spectroscopy (NIRS) provides a non-invasive means of continuously monitoring tissue oxygenation, which may be useful for diagnosis of acute compartment syndrome (ACS). Placement of these sensor pads on the surface of the skin must be such that light penetrates the intended compartment without inadvertently obtaining measurements of an adjacent compartment. The objective of this study is to examine whether the NIRS measurements of each compartment truly represent the tissue perfusion of the intended compartment, as indicated by the predictable decrease in muscle oxygenation of a given compartment in response to muscle fatigue. The investigators hypothesize that the tissue oxygenation values of the stimulated compartment will significantly decrease following muscle stimulation, indicating that the intended muscle compartment was successfully isolated. Additionally, the investigators hypothesize that NIRS values of unstimulated muscle compartments will not change from baseline.
| Condition | Intervention | Phase |
|---|---|---|
|
Acute Compartment Syndrome |
Behavioral: Muscle contraction |
Phase 1 |
| Study Type: | Observational |
| Study Design: | Time Perspective: Cross-Sectional |
| Official Title: | Ability of Near Infrared Spectroscopy to Isolate Compartments of the Extremity |
- Near infrared spectroscopy [ Time Frame: <30 minutes ] [ Designated as safety issue: No ]NIRS values will be measured before and after muscle fatigue
| Estimated Enrollment: | 63 |
| Groups/Cohorts | Assigned Interventions |
|---|---|
|
Exercise
NIRS values of all participants will be measured at baseline and following each 30-60 second exercise.
|
Behavioral: Muscle contraction
Participants will perform a 30-60 second exercise designed to cause a temporary decrease in muscle oxygenation of a specific muscle group.
|
Eligibility| Ages Eligible for Study: | 18 Years to 75 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
The study sample will consist of healthy volunteers recruited from the principle investigator's private practice.
Inclusion Criteria:
- 18-75 years old
- no current extremity injuries
- willing to provide written informed consent
Exclusion Criteria:
- history of any anatomy-altering surgery to the extremity in question
- history of peripheral vascular disease
- history of pulmonary disease
Contacts and Locations| United States, Georgia | |
| Athens Orthopedic Clinic, PA | |
| Athens, Georgia, United States, 30606 | |
| Principal Investigator: | Michael Shuler, MD | Athens Orthopedic Clinic, PA |
More Information
No publications provided
| Responsible Party: | Michael Shuler, J&M Shuler |
| ClinicalTrials.gov Identifier: | NCT01283451 History of Changes |
| Other Study ID Numbers: | NIRS-01 |
| Study First Received: | January 24, 2011 |
| Last Updated: | June 14, 2011 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by J&M Shuler:
|
near-infrared spectroscopy |
Additional relevant MeSH terms:
|
Compartment Syndromes Muscular Diseases Musculoskeletal Diseases Vascular Diseases Cardiovascular Diseases |
ClinicalTrials.gov processed this record on May 16, 2013