Assessment of Normal Value of Acoustic Radiation Force Impulse (ARFI) Elastography in HIV Patients
This is a prospective cohort single center study for assessment of normal value of acoustic radiation force impulse elastography and fibroscan in HIV patients without abnormal liver function and chronic liver disease.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Prospective Study for Assessment of Normal Value of Acoustic Radiation Force Impulse (ARFI) Elastography in HIV Patients Without Abnormal Liver Function and Chronic Liver Disease|
- Evaluation of ARFI velocity in HIV patients [ Time Frame: 2 years ] [ Designated as safety issue: No ]Measurement of ARFI velocity is non-invsive ultrasonographic technique. It is performed with a abdominal convex probe which is same probe as conventional ultrasonography. Short-duration acoustic radiation forces result in shear-wave propagation away from the region of excitation and are tracked using ultrasonic correlation-based methods. This results are called ARFI velocity which is expressed as meters per second
|Study Start Date:||October 2010|
|Estimated Study Completion Date:||June 2012|
|Estimated Primary Completion Date:||June 2012 (Final data collection date for primary outcome measure)|
HIV patients with normal liver status
HIV patients without abnormal liver function and chronic liver disease
Device: Acoustic radiation force impulse imaging
Acoustic radiation force impulse (ARFI) imaging were measured 10 times in each patient.The region of interest was chosen in an area where the normal liver parenchyma was at least 6 cm thick and free of large blood vessels was chosen. A measurement depth of 2 cm below the liver capsule was chosen to standardize the examination.
Other Name: ARFI imaging
HIV positive patients who have liver dysfunction have shown to be correlated with high mortality and morbidity. To date, ARFI elastography has been known to correlate with the degree of liver fibrosis in chronic liver disease. However, ARFI velocity has not yet been reported in HIV patients. The aim of this study was to identify the normal range of ARFI velocity and liver stiffness value by recruiting HIV patients without abnormal liver function and chronic liver disease.
|Contact: Seung Up Kim, MDemail@example.com|
|Contact: Kwang-Hyub Han, MDfirstname.lastname@example.org|
|Korea, Republic of|
|Seoul, Korea, Republic of, 120-752|
|Contact: Seung Up Kim, MD +82-2-2228-2108 email@example.com|
|Contact: Kwang-Hyub Han, MD +82-2-2228-1949 firstname.lastname@example.org|
|Sub-Investigator: Chang Young Son, MD|
|Study Chair:||Kwang-Hyub Han, MD||Yonsei University Colleage of Medicine|
|Principal Investigator:||Seung Up Kim, MD||Yonsei University Colleage of Medicine|