Aortic Stiffness in Chronic Kidney Disease Stage 2 to 4

This study has been completed.

Sponsor:

Collaborator:

Department of Nephrology, Klinikum rechts der Isar, München

Information provided by:

Technische Universität München

ClinicalTrials.gov Identifier:

NCT01279460

First received: January 17, 2011

Last updated: NA

Last verified: January 2011

History: No changes posted

Purpose

This study aimed to investigate in a cohort with chronic kidney disease the longitudinal relationship between aortic stiffness and renal function and mortality.

Condition
Decline in Renal Function

Study Type:	Observational
Study Design:	Observational Model: Cohort Time Perspective: Prospective
Official Title:	Evaluation of Aortic Stiffness in CKD II to IV

Resource links provided by NLM:

MedlinePlus related topics: Chronic Kidney Disease

U.S. FDA Resources

Further study details as provided by Technische Universität München:

Primary Outcome Measures:

combined renal end-point (>25% decline in renal function or start of renal replacement therapy) [ Time Frame: 24 months ] [ Designated as safety issue: No ]

Secondary Outcome Measures:

mortality [ Time Frame: 24 months ] [ Designated as safety issue: No ]

Enrollment:	167
Study Start Date:	October 2007
Study Completion Date:	December 2010
Primary Completion Date:	December 2010 (Final data collection date for primary outcome measure)

Groups/Cohorts
CKD Cohort of patients with renal insufficiency patients with renal insufficiency grade II-IV

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Non-Probability Sample

Study Population

Patients were enrolled in a prospective study of vascular stiffness and CV risk in patients with CKD stages 2 to 4. They were predominantly recruited from outpatients attending nephrology clinics at the Klinikum rechts der Isar der Technischen Universität München and at a private nephrological clinic in Weissenburg October 2007 to December 2008.

Criteria

Inclusion Criteria:

Age 18 or older
CKD 2-4

Exclusion Criteria:

pregnancy
history of malignant disease with a prognostic life expectancy less than 24 months
missing of written and informed consent

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT01279460

Locations

Germany
Klinikum rechts der Isar
München, Bavaria, Germany, 81675
Klinikum Weissenburg
Weissenburg, Bavaria, Germany, 91781

Sponsors and Collaborators

Technische Universität München

Department of Nephrology, Klinikum rechts der Isar, München

Investigators

Principal Investigator:

Marcus Baumann, M.D. PhD

Klinikum rechts der Isar of the Technical University Munich

More Information

Publications:

Pan CR, Roos M, Schmaderer C, Lutz J, Wang JG, Heemann U, Baumann M. Interrelationship between aortic stiffness and proteinuria in chronic kidney disease. J Hum Hypertens. 2010 Sep;24(9):593-9. Epub 2010 Jan 28.

Townsend RR, Wimmer NJ, Chirinos JA, Parsa A, Weir M, Perumal K, Lash JP, Chen J, Steigerwalt SP, Flack J, Go AS, Rafey M, Rahman M, Sheridan A, Gadegbeku CA, Robinson NA, Joffe M. Aortic PWV in chronic kidney disease: a CRIC ancillary study. Am J Hypertens. 2010 Mar;23(3):282-9. Epub 2009 Dec 17.

Responsible Party:	PD. Dr. med. Marcus Baumann, M.D., PhD, Technical University of Munich, Klinikum rechts der Isar, Department of nephrology
ClinicalTrials.gov Identifier:	NCT01279460 History of Changes
Other Study ID Numbers:	Munich-CKD-PWA
Study First Received:	January 17, 2011
Last Updated:	January 17, 2011
Health Authority:	Ethikkommission der Fakultät für Medizin der Technischen Universität München, Germany:

Keywords provided by Technische Universität München:

chronic kidney disease
CKD
pulse wave velocity
PWV

Additional relevant MeSH terms:

Kidney Diseases
Renal Insufficiency, Chronic
Urologic Diseases
Renal Insufficiency

ClinicalTrials.gov processed this record on May 23, 2013

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