Metabonomics Fingerprinting of Multiple Trauma
The aim of this study is to establish plasma metabonomics fingerprinting atlas for severe multiple trauma patient using 1H nuclear magnetic resonance (NMR) based metabonomics methodology and advanced mathematics tools.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Establishing 1H Nuclear Magnetic Resonance (NMR) Based Metabonomics Fingerprinting Profile for Severe Poly Trauma Patients|
- Mortality at hospitalization [ Time Frame: Death events from admission to discharge(up to 10 weeks) ] [ Designated as safety issue: No ]
- Multi Organ Failure(MOF) [ Time Frame: MOF events occurence from admission to discharge(up to 10 weeks) ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples Without DNA
Plasma from peripheral blood.
|Study Start Date:||June 2010|
|Study Completion Date:||June 2011|
|Primary Completion Date:||June 2011 (Final data collection date for primary outcome measure)|
20 Patients suffering from poly trauma who meet inclusion criteria would be recruited
20 healthy volunteers would be recruited to obtain basal metabonomics fingerprinting
Metabonomics is a set of measurements of the dynamic metabolic responses of living systems to stimuli or modifications. This field of study developed from the application of nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry as tools for the study of complex biofluids. Metabonomics is one of the emerging fields of systemic biology researches concerned with the high-throughput identification, quantification and characterization of small molecule metabolites. A metabonomics fingerprinting can be defined as the complete complement of all small molecule (<1500 Da) metabolites found in a specific cell, body fluid, organ or organism.
Severe poly trauma involves complex injuries that consist of multiple pathological mechanisms involving cytotoxic, oxidation stress and immune-endocrine. The complexity of the pathological physiology and biochemistry process are determined not only by the initial mechanical assault, but also by secondary processes including abnormality of inflammation regulation, ischemia, anoxia, free-radical formation, and immune dysfunction that occur over hours and days following the injury. For the clinical perspective, one of the key difficulties is to identify the most at-risk patients who could develop multiple organ failures and consequently death.
This study aims to establish the dynamics of NMR-based metabonomics fingerprinting of severe multi-trauma patients in order to provide a possible multiple organs failure (MOF) or death event prediction.
|Sichuan Academy of Medical Sciences, Sichuan Provincial Hospital, Dept. Trauma Surgery|
|Chengdu, Sichuan, China, 610101|
|Study Chair:||Hua Jiang, M.D||Sichuan Academy of Medical Sciences|
|Principal Investigator:||Zhi-Yuan Zhou, M.S||Sichuan Academy of Medical Sciences|
|Principal Investigator:||Ming-Wei Sun, M.D||Sichuan Academy of Medical Sciences|