Study of Postprandial Incretin Response in Women With Gestational Diabetes

This study has been completed.
Sponsor:
Collaborators:
The Danish Diabetes Association
Aase and Ejnar Danielsens Foundation
The Novo Nordic Foundation
Information provided by:
University Hospital, Gentofte, Copenhagen
ClinicalTrials.gov Identifier:
NCT01274052
First received: January 10, 2011
Last updated: NA
Last verified: January 2011
History: No changes posted
  Purpose

The researchers investigated nineteen pregnant women in third trimester and again postpartum. At the experimental days we performed a mealtest and drew blood for analyses of glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), insulin, C-peptide and glucagon.

The researchers aimed to investigate whether women with gestational diabetes mellitus exhibit decreased postprandial GLP-1 responses, and if so, whether this deficiency ceases following delivery when normal glucose tolerance is reestablished.


Condition Intervention
Gestational Diabetes Mellitus
Other: Meal test

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Reduced Postprandial GLP-1 Response in Gestational Diabetes Mellitus: a Fully Reversible Phenomenon

Resource links provided by NLM:


Further study details as provided by University Hospital, Gentofte, Copenhagen:

Biospecimen Retention:   Samples Without DNA

Blood Plasma


Enrollment: 19
Study Start Date: March 2007
Study Completion Date: July 2008
Primary Completion Date: July 2008 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Gestational Diabetes Mellitus
Women with Gestational Diabetes Mellitus
Other: Meal test
Liquid meal test
Normal Glucose Tolerance
Women with Normal Glucose Tolerance
Other: Meal test
Liquid meal test

Detailed Description:

The researchers investigated nineteen pregnant women in third trimester and again postpartum. At the experimental days we performed a mealtest and drew blood for analyses of glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), insulin, C-peptide and glucagon.

The researchers aimed to investigate whether women with gestational diabetes mellitus exhibit decreased postprandial GLP-1 responses, and if so, whether this deficiency ceases following delivery when normal glucose tolerance is reestablished.

  Eligibility

Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

Healthy pregnant woman were examined with a 75 g oral glucose tolerance test. Subjects with plasma glucose (PG) values at 120 min >9.0 mmol/l were diagnosed with gestational diabetes and subjects with PG <9.0 mmol/l were enrolled as healthy controls.

Criteria

Inclusion Criteria:

  • Normal haemoblobin
  • Willingness to participate

Exclusion Criteria:

  • First degree relative with diabetes
  • Diabetes before pregnancy
  • Positive islet cell- and GAD-65 autoantibodies
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01274052

Locations
Denmark
Department of Internal Medicine, Glostrup Hospital
Glostrup, Denmark, 2600
Sponsors and Collaborators
University Hospital, Gentofte, Copenhagen
The Danish Diabetes Association
Aase and Ejnar Danielsens Foundation
The Novo Nordic Foundation
Investigators
Principal Investigator: Filip K Knop, MD PhD Diabetes Research Division, Gentofte Hopsital
  More Information

No publications provided

Responsible Party: Filip K. Knop, MD PhD, Department of Internal Medicine F, University Hospital, Gentofte, Copenhagen
ClinicalTrials.gov Identifier: NCT01274052     History of Changes
Other Study ID Numbers: KA-060015
Study First Received: January 10, 2011
Last Updated: January 10, 2011
Health Authority: Denmark: Ethics Committee

Keywords provided by University Hospital, Gentofte, Copenhagen:
Gestational diabetes mellitus
Meal test
Incretin hormones
Glucagon-like peptide-1 (GLP-1)
Glucose-dependent insulinotropic polypeptide
Insulin
C-peptide
Glucagon

Additional relevant MeSH terms:
Diabetes Mellitus
Diabetes, Gestational
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Pregnancy Complications
Gastric Inhibitory Polypeptide
Incretins
Gastrointestinal Agents
Therapeutic Uses
Pharmacologic Actions
Hormones
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs

ClinicalTrials.gov processed this record on August 18, 2014