Clinical and Biochemical Effects of Multipass Hemodialysis (MHD)
The purpose of this study is to investigate whether recycled dialysis fluid can supply enough clearance for hemodiaysis patients.
|Study Design:||Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Clinical and Biochemical Effects of Multipass Hemodialysis|
- Urea Kt/V [ Time Frame: 9 hours ] [ Designated as safety issue: No ]
- Creatinine clearance [ Time Frame: 9 hours ] [ Designated as safety issue: No ]
- Patient symptoms [ Time Frame: 9 hours ] [ Designated as safety issue: No ]
|Study Start Date:||March 2011|
|Study Completion Date:||June 2011|
|Primary Completion Date:||June 2011 (Final data collection date for primary outcome measure)|
Active Comparator: conventional HD
conventional 4-hour HD
Device: Multipass hemodialysis
8-hour dialysis using a recycled dialysis bath of 25-30 l
Conventional hemodialysis uses large amounts of water, which hinders travel possibilies for home hemodialysis (HD) patients. We have developed a recycling system using 25-30 l dialysate per dialysis. In vitro investigations show that this results in adequate dialysis.
12 HD patients will be studied during two dialysis sessions. The first HD will be a conventional 4 hour dialysis, using single pass dialysate. The second will be an 8-hour HD using multipass (recycled) dialysate 25-30 l. Clearance of urea, creatinine, phosphate and cobalamin will be measured both in the patient and the dialysate. Patient symptoms will be recorded.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01267760
|Herlev, Denmark, 2880|
|Principal Investigator:||James G Heaf, MD DMSc||Herlev Hospital|