Development of Magnetic Resonance Spectroscopy Techniques for Imaging Metabolites and Neurotransmitters in Human Brain
- Magnetic resonance imaging (MRI) is a widely used scanning technique to obtain images of the human body and evaluate activity in the brain. A particular MRI method called magnetic resonance spectroscopy (MRS) can be used to study brain chemistry as well, which may help researchers who are studying new treatments for psychiatric illnesses. Researchers are interested in improving current MRI and MRS techniques, as well as developing new MRI and MRS techniques to view and measure brain chemicals and brain activity.
- To implement, develop, and optimize brain chemistry imaging techniques using magnetic resonance imaging and magnetic resonance spectroscopy.
- Healthy individuals between 18 and 65 years of age.
- This study will involve a screening visit and a scanning visit at the National Institutes of Health Clinical Center.
- Participants will be screened with a full medical and physical examination, blood and urine tests, and neurological testing.
- During the second visit, participants will have an MRI scan of the brain. (Participants who have received an MRI within the past year will not need to have a second one; the images of the previous scan will be used for this study.) All participants will then have an MRS scan using the same scanning equipment.
|Study Design:||Time Perspective: Prospective|
|Official Title:||Development of Magnetic Resonance Spectroscopic Imaging Techniques for Imaging Metabolites and Neurotransmitters in Human Brain|
- The primary outcome is the quality of the MR spectroscopy which includes spectrum signal-to-noise (SNR) ratio, spectral lineshape, linewidth, and resolution.
- The secondary outcome is the performance improvements of the scanner hardware, software and methodology.
|Study Start Date:||December 2010|
Magnetic resonance spectroscopy (MRS) is identical to MRI except that the metabolite signal, rather than the dominant water signal, is measured. By using water suppression techniques, MRS can monitor levels of important brain metabolites and neurotransmitters such as N-acetylaspartate (NAA), creatine, choline, lactate, myo-inositol, and glutamate/glutamine. Gamma aminobutyric acid (GABA) (the major inhibitory neurotransmitter in the brain) and glutathione (an important marker of oxidative stress and aging) are overlapped spectrally by other more intense metabolites such as creatine. Thus, spectral editing techniques are needed to reveal GABA and glutathione in the proton MRS spectra.
This protocol proposes two main goals. First, to implement and optimize current MRS methods published in the literature for the imaging of GABA and glutathione. Second, to further develop new methods for use in similar brain MRS applications.
To develop and optimize in vivo MRS methods, 150 healthy volunteers will be recruited over a period of three years. The subjects will be aged 18-65 years, and include representative numbers of males, females, and minorities.
The experiments will be performed on the GE 3T Siemens 3T and 7T MRI scanners located at the NIH In Vivo NMR Research Center. In the first portion of the study, a clinical MRI will be performed to ensure the subject has no abnormal brain conditions. In the second portion of the study, MRS scans will be performed in various system and pulse parameter combinations. No medications will be involved. Total scan time during the MRS scan will be one to two hours long.
We expect to obtain high quality GABA and glutathione spectroscopy imaging from healthy volunteers that will help establish accurate and reliable spectroscopy methods for clinical investigators to perform non-invasive studies of psychiatric and neurological disorders.
|Contact: Christopher Johnson||(301) firstname.lastname@example.org|
|Contact: Shizhe Steve Li, Ph.D.||(301) email@example.com|
|United States, Maryland|
|National Institutes of Health Clinical Center, 9000 Rockville Pike||Recruiting|
|Bethesda, Maryland, United States, 20892|
|Contact: For more information at the NIH Clinical Center contact Patient Recruitment and Public Liaison Office (PRPL) 800-411-1222 ext TTY8664111010 firstname.lastname@example.org|
|Principal Investigator:||Shizhe Steve Li, Ph.D.||National Institute of Mental Health (NIMH)|