Study of the Fixation of Various Vectors in PET/CT in Patients With a With Lung Cancer Before and During of CRT or RT (RTEP4)

This study has been completed.
Sponsor:
Information provided by:
Centre Henri Becquerel
ClinicalTrials.gov Identifier:
NCT01261585
First received: December 15, 2010
Last updated: NA
Last verified: January 2009
History: No changes posted
  Purpose

Study of the modification of the fixation(binding) of Fluoro-2-deoxy-D-glucose (FDG), fluoro-misonidazole (FMISO) and 3'deoxy-3-fluoro-thymidine deoxy-3-fluoro-thymidine (FLT) measured in tomography by broadcast(emission,issue) of positrons (PET) at patients before and in the course of exclusive radiotherapy or concomitant radiochemotherapy for primitive bronchial cancer.

This protocle allows to study the simultaneous variations of the metabolism, the hypoxie and the cellular proliferation by PET SCAN at 5 patients reached(affected) by a primitive bronchial cancer in the course of exclusive radiotherapy for primitive bronchial cancer not small cell lung.

The investigators are also going to study several scenarii of optimization of the radiotherapy according to the variations of the tumoral metabolism, the hypoxie and the cellular proliferation measured in the course of radiotherapy (theoretical study on console using the scanner and the various examinations).


Condition
Bronchial Neoplasms
Carcinoma, Non-Small-Cell Lung

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Study of the Modification of the Fixation of FDG, F-Miso and FLT Measured in PET/CT at Patients Before and in the Course of Exclusive Radiotherapy or Concomitant Radiochemotherapy for Primitive Bronchial Cancer

Resource links provided by NLM:


Further study details as provided by Centre Henri Becquerel:

Enrollment: 5
Study Start Date: December 2008
Study Completion Date: December 2009
Primary Completion Date: November 2009 (Final data collection date for primary outcome measure)
  Eligibility

Ages Eligible for Study:   18 Years to 75 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

Diagnosed patients with non-small-cell lung carcinoma

Criteria

Inclusion Criteria:

  • patients with non-small-cell lung carcinoma hitologicaly proved
  • Candidate patients in a treatment with aim guardian by exclusive thoracic radiotherapy or of concomitant radiochemotherapy (tumoral dose superior to 60 Gy) ( n=5 ).
  • Measurable tumor according to the criteria of evaluation RECIST

Exclusion Criteria:

  • Histology other one than primitive bronchial cancer not in small cells lung
  • The patients for whom no tumoral target is assessable (forgiveness completes after first chemotherapy, operated patients).
  • Patients for whom a radiotherapy with curative aim is not indicated (tumoral extension, metastases, general state, co-morbidity).
  • Patient having benefited from an examination PET in the FDG with in more than 4 weeks and for which a new PET in the FDG is not necessary with in the framework of its disease
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01261585

Locations
France
Centre Henri Becquerel
Rouen, Hate Normandie, France, 76000
Sponsors and Collaborators
Centre Henri Becquerel
Investigators
Principal Investigator: GUERNOU Mohamed, MD CHBecquerel
Study Director: VERA Pierre, MD phD CHBecquerel
  More Information

No publications provided

Responsible Party: Mohamed GUERNOU MD, Centre Henri Becquerel
ClinicalTrials.gov Identifier: NCT01261585     History of Changes
Other Study ID Numbers: CHB 08-01
Study First Received: December 15, 2010
Last Updated: December 15, 2010
Health Authority: France: Institutional Ethical Committee

Keywords provided by Centre Henri Becquerel:
Positron-Emission Tomography
PET Scan
FDG
FLT
FMISO
Non-Small-Cell Lung Carcinoma
chemo-Radiation Oncology
SUV

Additional relevant MeSH terms:
Bronchial Neoplasms
Neoplasms
Carcinoma
Carcinoma, Non-Small-Cell Lung
Lung Neoplasms
Respiratory Tract Neoplasms
Thoracic Neoplasms
Neoplasms by Site
Bronchial Diseases
Respiratory Tract Diseases
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Carcinoma, Bronchogenic
Lung Diseases

ClinicalTrials.gov processed this record on April 17, 2014