Effects of Expiratory Pressure on Arterial Oxygenation During Hypoxia (hypex)
Altitude tolerance correlates with the level of oxygenation achieved. The aim of the present study is to investigate whether increased expiratory pressure within the thorax is able to improve oxygenation during hypoxic hypoxia.
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||Arterial Oxygenation During Hypoxia : Effects of an Added Expiratory Resistance|
- SpO2 [ Time Frame: mean over 1 minute ] [ Designated as safety issue: No ]after three minutes of PEEP vs spontaneous breathing
- peripheral HbO2/DeoxyHb [ Time Frame: 1 min ] [ Designated as safety issue: No ]after three minutes of PEEP / PLB vs. spontaneous breathing
- cardiac output [ Time Frame: mean over 1 min ] [ Designated as safety issue: No ]after three min of PEEP vs. spontaneous breathing
- pattern of breathing (fR, VT, PETCO2) [ Time Frame: 1 min ] [ Designated as safety issue: No ]after three min of PEEP vs. spontaneous breathing
|Study Start Date:||February 2011|
healthy active subjects
with and without high altitude intolerance
Device: threshold PEEP
Various set of pressures : 0, 5, 10 cm H20; pursed lips breathing
Two types of procedures will be tested in a random order, interspaced by resting periods : threshold PEEP set at 5,10 and 15 cm of water and pursed leap breathing.
Subjects will be tested at rest, and during light exercise (30% of sea level predicted VO2max).
FiO2 will be set at 12.5% (4000 m). fc, VE, PETCO2, TA, ECG, cardiac output, and tissular oxygenation will be monitored.
|Contact: Bernard Wuyam, MD, PhD||33 (0)4 76 76 93 03||BWuyam@chu-grenoble.fr|
|CHU de Grenoble||Recruiting|
|La Tronche, Isere, France, 38000|
|Contact: BERNARD WUYAM, MD? PhD (33) 04 76 76 93 03 BWuyam@chu-grenoble.fr|
|Contact: hugo nespoulet, Bsc 04 76 76 55 16 HNespoulet@chu-grenoble.fr|
|Principal Investigator: Bernard Wuyam, MD, PhD|
|Sub-Investigator: Samuel Vergès, PhD|
|Principal Investigator:||Bernard Wuyam, MD, PhD||University Hospital, Grenoble|
|Study Director:||Samuel Vergès, PhD||Institut National de la Santé Et de la Recherche Médicale, France|
|Study Chair:||Hugo NESPOULET, MsC||Université Joseph Fourier|