Quantification of Human Adipogenesis
This pilot study is using a novel technology to measure the rate of turnover of new fat cells. There are currently two active phases of this study.
- The first phase involves a 3-night stay in the hospital, and 2 fat biopsies over a one month period. The fat biopsies will be looked at under a special microscope that can tell which fat cells have been recently made.
- The second phase involves a 1-day (no overnight) stay in the hospital, and 3 fat biopsies over a 6 month period.
|Study Design:||Time Perspective: Prospective|
|Official Title:||Quantification of Human Adipogenesis|
- Quantifying human adipogenesis-counting the number of new fat cells. [ Time Frame: 4 weeks-7 months ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples Without DNA
Fat biopsy. Oral mucosal smear. White blood cells.
|Study Start Date:||December 2010|
|Estimated Study Completion Date:||December 2015|
|Estimated Primary Completion Date:||December 2014 (Final data collection date for primary outcome measure)|
18-49 year old healthy men and women. Free of significant chronic medical illness and illicit substance abuse. Body ass index from 20 to 27. Must be able to easily 'pinch an inch' of belly fat.
Biological: 15N-Thymidine, 2H-Water
Stable isotope 15N-thymidine, infused IV (15mg/hour) for 72 hours (phase 1 pilot).
Stable isotope 2H-water, ingested by mouth once per day for 3 days (phase 1 pilot) or 28 days (phase 2 pilot).
|Contact: Matthew L Steinhauser, MD||617 732 5500 ext firstname.lastname@example.org|
|United States, Massachusetts|
|Brigham and Women's Hospital||Recruiting|
|Boston, Massachusetts, United States, 02115|
|Contact: Matthew L Steinhauser, MD 617-732-5500 ext 13202 email@example.com|
|Principal Investigator:||Matthew L Steinhauser, MD||Brigham and Women's Hospital|