Trial record 1 of 1 for:    CRONA
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Long-term Caloric Restriction and Cellular Aging Markers (CRONA)

This study has been completed.
Sponsor:
Collaborator:
Robert Wood Johnson Foundation
Information provided by (Responsible Party):
University of California, San Francisco
ClinicalTrials.gov Identifier:
NCT01256840
First received: December 2, 2010
Last updated: September 20, 2011
Last verified: September 2011
  Purpose

The purpose of this study is to see whether people who have restricted the number of calories they eat for a long period of time, compared to normal-eating and obese people, have markers of cellular aging that look younger.


Condition
Aging

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Caloric Restriction With Optimal Nutrition and Aging Study

Further study details as provided by University of California, San Francisco:

Primary Outcome Measures:
  • Telomere length [ Time Frame: One day ] [ Designated as safety issue: No ]
    This study is not a clinical trial, but the UCSF Committee on Human Research requires registration with clinicaltrials.gov. It is a ONE TIME POINT study, where we get a simple blood draw from people from three groups - calorie restricting, normal eating, and obese. Therefore, there IS NO FOLLOW UP/time frame. The outcome measure is assessed on the day of the study. Telomere length is a marker of cellular aging and is used to understand how the cells are aging. We will investigate whether long-term caloric restriction is associated cross-sectionally with longer telomere length (less aging).


Biospecimen Retention:   Samples With DNA

Whole blood, serum.


Estimated Enrollment: 75
Study Start Date: December 2010
Groups/Cohorts
Calorie Restricting Group
Normal-eating controls
Obese comparison group

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Community sample and Calorie Restriction Society

Criteria

Inclusion Criteria:

  • Calorie restricting group: Self-reported caloric restriction for at least two years
  • Calorie restriction group: BMI below 23
  • Normal eating control: Normal eating (no history of caloric restriction) for two years
  • Normal eating control: BMI below 30
  • Obese comparison group: BMI above 30
  • Obese comparison group: Normal eating (no history of caloric restriction) for two years

Exclusion Criteria:

  • Regular smoker for the past six months
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01256840

Locations
United States, California
University of California
San Francisco, California, United States, 94118
Sponsors and Collaborators
University of California, San Francisco
Robert Wood Johnson Foundation
Investigators
Principal Investigator: A. Janet Tomiyama, Ph.D. University of California, San Francisco
  More Information

No publications provided

Responsible Party: University of California, San Francisco
ClinicalTrials.gov Identifier: NCT01256840     History of Changes
Other Study ID Numbers: UCSF-CHR-10-01323
Study First Received: December 2, 2010
Last Updated: September 20, 2011
Health Authority: United States: Institutional Review Board

ClinicalTrials.gov processed this record on August 18, 2014