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Motor-related Cortical Potential in Patients With Essential Tremor

This study has been completed.
Sponsor:
Collaborator:
National Science Council, Taiwan
Information provided by:
China Medical University Hospital
ClinicalTrials.gov Identifier:
NCT01250067
First received: November 26, 2010
Last updated: NA
Last verified: September 2005
History: No changes posted
  Purpose

In this proposal, in addition to the conventional MRCP recording, the dipoles and sources of the different subcomponents of MRCP will also be analyzed with the brain electric source analysis (BESA) to evaluate the difference in the solutions and source strength underlying the MRCP between normal controls and patients with ET.


Condition Intervention
Essential Tremor
Movement-related Cortical Potentials
Procedure: Motor-related cortical potential (Procedure)

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Diagnostic

Resource links provided by NLM:


Further study details as provided by China Medical University Hospital:

Study Start Date: August 2003
Detailed Description:

Essential tremor (ET) is a common disorder with unknown etiology and pathogenesis. Typically described as a postural tremor, ET often has a marked kinetic component suggesting cerebellar involvement in the pathogenesis of the tremor. The assumption has been illustrated by both positron emission tomography and functional magnetic resonance imaging studies, which revealed that blood flow and activity of the cerebellum were increased in ET patients as compared to the normal controls. In contrast to the cumulative body of imaging evidence, the physiological bases to link the ET and cerebellar functional alternation are scarce. Studies with tandem gait analysis have revealed 25% abnormality of ET patients and surface electromyographic study has found a delay in the second agonist burst during rapid wrist movements suggesting the possible role of cerebellar functional alternation in the generation of ET. In addition, since the tremor of ET tends to appear in the movement ignition or during postural maintenance, it is conceivable that this sort of tremor might exert certain impact on the programming and preparation of the limb movement. Thus it would be appropriate to adopt a tool, which can concomitantly assess the cerebellar function and movement preparation, to investigate the patients with ET. In this proposal, we will record movement-related cortical potentials (MRCP) in ET patients. MRCP is a slow negative shift starting 1-1.5 sec before volitional movement. It consists of at least 3 subcomponents, the Bereitschaftspotential, the negative slope, and the motor potential. The generators crucial for the generation of MRCP include cerebellum, motor and motor association cortex. Thus MRCP seems to be an appropriate tool to assess the patients with ET, in whom the trivial cerebellar functional alternation could be responsible for the tremor generation and motor preparation might be hampered concomitantly. In this proposal, in addition to the conventional MRCP recording, the dipoles and sources of the different subcomponents of MRCP will also be analyzed with the brain electric source analysis (BESA) to evaluate the difference in the solutions and source strength underlying the MRCP between normal controls and patients with ET.

  Eligibility

Ages Eligible for Study:   20 Years to 75 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Bilateral postural tremor with or without kinetic tremor involving hands or forearms, which is visible and persistent, and long-standing in duration (>5 years). Tremor involving body parts other than upper limbs may be present, the tremor may be asymmetrical, amplitude may fluctuate, and the tremor may or may not produce disability.

Exclusion Criteria:

  • Neurological signs, except for Froment's sign
  • Causes of enhanced physiologic tremor
  • Concurrent or recent exposure to tremorgenic drugs
  • Direct or indirect trauma to the central and peripheral nervous system
  • Historical or clinical evidence of psychogenic origins of tremor
  • Convincing evidence of sudden onset or evidence of stepwise deterioration
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01250067

Locations
Taiwan
China Medical University Hospital
Taichung, Taiwan, 40402
Sponsors and Collaborators
China Medical University Hospital
National Science Council, Taiwan
Investigators
Principal Investigator: Chon-Haw Tsai, MD, Ph.D. Department of Neurology, China Medical University Hospital
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT01250067     History of Changes
Other Study ID Numbers: NSC92-2314-B-039-016
Study First Received: November 26, 2010
Last Updated: November 26, 2010
Health Authority: Taiwan: Department of Health

Additional relevant MeSH terms:
Essential Tremor
Tremor
Central Nervous System Diseases
Dyskinesias
Movement Disorders
Nervous System Diseases
Neurologic Manifestations
Signs and Symptoms

ClinicalTrials.gov processed this record on November 20, 2014