The Effect of Artificial Sweeteners on Blood Glucose Response

This study has been withdrawn prior to enrollment.
Sponsor:
Information provided by:
Northumbria University
ClinicalTrials.gov Identifier:
NCT01246492
First received: November 22, 2010
Last updated: May 17, 2012
Last verified: May 2012
  Purpose

The purpose of this study is to determine whether the presece of the artificial sweeteners aspartame, saccharin and asceulfame-k affect the blood glucose responses to an orally incested glucose solution.


Condition Intervention
Taste Receptors
Nutrient Sensing
Intestinal Absorption
Blood Glucose
Appetite
Dietary Supplement: Artificial Sweeteners

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double Blind (Subject, Investigator)
Primary Purpose: Basic Science
Official Title: The Effect of Artificial Sweeteners on Blood Glucose Response

Resource links provided by NLM:


Further study details as provided by Northumbria University:

Primary Outcome Measures:
  • Blood glucose response [ Time Frame: 90 min ] [ Designated as safety issue: No ]
    Blood glucose will be determined at baseline and for 90 min following the consumption of the test drinks


Secondary Outcome Measures:
  • Subjective appetite [ Time Frame: 90 min ] [ Designated as safety issue: No ]
    Subjective appetite ratings will be collected at baseline and for 90 min following the consumption of the test drinks


Enrollment: 0
Study Start Date: November 2010
Estimated Study Completion Date: May 2011
Estimated Primary Completion Date: May 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Placebo Comparator: 45g glucose
glucose water
Dietary Supplement: Artificial Sweeteners
A 400mL drink sweetened with 45g glucose and artificial sweetener will be consumed orally
Active Comparator: 45g glucose + 150mg aspartame
glucose water aspartame
Dietary Supplement: Artificial Sweeteners
A 400mL drink sweetened with 45g glucose and artificial sweetener will be consumed orally
Active Comparator: 45g glucose + 20 mg saccharin
glucose water saccharin
Dietary Supplement: Artificial Sweeteners
A 400mL drink sweetened with 45g glucose and artificial sweetener will be consumed orally
Active Comparator: 45g glucose + 85mg asculfame - K
glucose water aseulfame- k
Dietary Supplement: Artificial Sweeteners
A 400mL drink sweetened with 45g glucose and artificial sweetener will be consumed orally

Detailed Description:

Sweet taste receptors, similar to those located on the lingual taste buds have been located along in the lining of the gut. Recent studies have demonstrated that activation of these sweetness taste receptors, either by sugars such as glucose, fructose, lactose, or artificial sweeteners such as saccharin and aspartame can influence the way nutrients, including glucose are absorbed from the gut into the bloodstream. Studies in animal models have shown that activation of the sweet taste receptors can increase the expression of the sodium-dependant glucose transporter 1 (SGLT1) and glucose transporter 2 (GLUT2) which transport glucose from the lumen into the bloodstream. Thus providing a potential mechanism by which glucose uptake can be regulated. Although artificial sweeteners stimulate the sweet taste receptors, they have little nutritive value, so that when they are consumed in the absence of any other nutrients there is little effect on blood glucose response. However, the effects of consuming artificial sweeteners in combination with sugars such as glucose is unclear. The purpose of this study is to investigate whether the addition of artificial sweeteners to an orally consumed glucose solution affects the rate at which the glucose appears in the blood.

  Eligibility

Ages Eligible for Study:   18 Years to 45 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy subjects
  • Aged 18-45 years
  • BMI (19-25 kg/m2)
  • Weight stable in past 3 months

Exclusion Criteria:

  • Smoking
  • Females who are pregnant of breastfeeding
  • Regular intake of emdication, other than females taking oral contraceptives
  • Medical illness
  • Gastrointestinal disorders
  • Food allergies
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01246492

Locations
United Kingdom
Brain, Performance and Nutrition Research Centre- Northumbria University
Newcastle-Upon Tyne, United Kingdom, NE1 8ST
Sponsors and Collaborators
Northumbria University
Investigators
Principal Investigator: Nerys M Astbury, PhD Northumbria University
  More Information

No publications provided

Responsible Party: Brain, Performance and Nutrition Research Centre, Northumbria University
ClinicalTrials.gov Identifier: NCT01246492     History of Changes
Other Study ID Numbers: 34AK1
Study First Received: November 22, 2010
Last Updated: May 17, 2012
Health Authority: United Kingdom: Research Ethics Committee

ClinicalTrials.gov processed this record on October 19, 2014