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Inflammatory Markers in Exhaled Breath Condensates From Asthmatic Patients

This study has been completed.
Sponsor:
Collaborator:
Mahidol University
Information provided by:
Chulalongkorn University
ClinicalTrials.gov Identifier:
NCT01246414
First received: January 4, 2010
Last updated: November 22, 2010
Last verified: November 2010
History of Changes
  Purpose

This study aims to compare the inflammatory mediators in exhaled breathe condensates from allergic and non-allergic asthmatic patients.


Condition
Asthma

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Inflammatory Markers in Exhaled Breath Condensates From Asthmatic Patients

Resource links provided by NLM:

MedlinePlus related topics: Asthma
U.S. FDA Resources

Further study details as provided by Chulalongkorn University:

Primary Outcome Measures:
  • Levels of inflammatory cytokines in exhaled breathe condensates [ Time Frame: 4 months ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples Without DNA

Exhaled breathe condensates


Enrollment: 38
Study Start Date: January 2010
Study Completion Date: May 2010
Primary Completion Date: April 2010 (Final data collection date for primary outcome measure)
Groups/Cohorts
Allergic asthma
Patients with allergic asthma
Non-allergic asthma
Patients with non-allergic asthma
Non-asthmatic controls
Non-asthmatic controls

  Eligibility

Ages Eligible for Study:   15 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Asthmatic patients in Allergy clinic, King Chulalongkorn Memorial Hospital (10 allergic and 10 non-allergic) and 10 non-asthmatic controls will be enrolled to this study to collect exhaled breathe condensates (EBC) and measure levels of inflammatory cytokines in EBC

Criteria

Inclusion Criteria:

  1. Have been diagnosed as asthma at least 6 months before enrolled to the study
  2. Known skin prick test results to aeroallergens ; either positive or negative
  3. 15-65 years of age

Exclusion Criteria:

  1. On oral or inhaled corticosteroids within 1 month before the study
  2. Having asthma exacerbation
  3. Being pregnant
  4. Suffering from severe systemic disease/ in bad health
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01246414

Locations
Thailand
Chulalongkorn University
Bangkok, Thailand, 10330
Sponsors and Collaborators
Chulalongkorn University
Mahidol University
Investigators
Principal Investigator: Jettanong Klaewsongkram, MD Chulalongkorn University
  More Information

No publications provided

Responsible Party: Jettanong Klaewsongkram, MD., Chulalongkorn University
ClinicalTrials.gov Identifier: NCT01246414     History of Changes
Other Study ID Numbers: Chula-ARC 001/10
Study First Received: January 4, 2010
Last Updated: November 22, 2010
Health Authority: Thailand: Ethical Committee

Keywords provided by Chulalongkorn University:
Asthma
Exhaled breath condensates
Cytokines

Additional relevant MeSH terms:
Asthma
Bronchial Diseases
Respiratory Tract Diseases
Lung Diseases, Obstructive
Lung Diseases
 Respiratory Hypersensitivity
Hypersensitivity, Immediate
Hypersensitivity
Immune System Diseases

ClinicalTrials.gov processed this record on May 21, 2013