Inflammatory Markers in Exhaled Breath Condensates From Asthmatic Patients

This study has been completed.
Sponsor:
Collaborator:
Mahidol University
Information provided by:
Chulalongkorn University
ClinicalTrials.gov Identifier:
NCT01246414
First received: January 4, 2010
Last updated: November 22, 2010
Last verified: November 2010
  Purpose

This study aims to compare the inflammatory mediators in exhaled breathe condensates from allergic and non-allergic asthmatic patients.


Condition
Asthma

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Inflammatory Markers in Exhaled Breath Condensates From Asthmatic Patients

Resource links provided by NLM:


Further study details as provided by Chulalongkorn University:

Primary Outcome Measures:
  • Levels of inflammatory cytokines in exhaled breathe condensates [ Time Frame: 4 months ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples Without DNA

Exhaled breathe condensates


Enrollment: 38
Study Start Date: January 2010
Study Completion Date: May 2010
Primary Completion Date: April 2010 (Final data collection date for primary outcome measure)
Groups/Cohorts
Allergic asthma
Patients with allergic asthma
Non-allergic asthma
Patients with non-allergic asthma
Non-asthmatic controls
Non-asthmatic controls

  Eligibility

Ages Eligible for Study:   15 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Asthmatic patients in Allergy clinic, King Chulalongkorn Memorial Hospital (10 allergic and 10 non-allergic) and 10 non-asthmatic controls will be enrolled to this study to collect exhaled breathe condensates (EBC) and measure levels of inflammatory cytokines in EBC

Criteria

Inclusion Criteria:

  1. Have been diagnosed as asthma at least 6 months before enrolled to the study
  2. Known skin prick test results to aeroallergens ; either positive or negative
  3. 15-65 years of age

Exclusion Criteria:

  1. On oral or inhaled corticosteroids within 1 month before the study
  2. Having asthma exacerbation
  3. Being pregnant
  4. Suffering from severe systemic disease/ in bad health
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01246414

Locations
Thailand
Chulalongkorn University
Bangkok, Thailand, 10330
Sponsors and Collaborators
Chulalongkorn University
Mahidol University
Investigators
Principal Investigator: Jettanong Klaewsongkram, MD Chulalongkorn University
  More Information

No publications provided by Chulalongkorn University

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Jettanong Klaewsongkram, MD., Chulalongkorn University
ClinicalTrials.gov Identifier: NCT01246414     History of Changes
Other Study ID Numbers: Chula-ARC 001/10
Study First Received: January 4, 2010
Last Updated: November 22, 2010
Health Authority: Thailand: Ethical Committee

Keywords provided by Chulalongkorn University:
Asthma
Exhaled breath condensates
Cytokines

Additional relevant MeSH terms:
Asthma
Bronchial Diseases
Respiratory Tract Diseases
Lung Diseases, Obstructive
Lung Diseases
Respiratory Hypersensitivity
Hypersensitivity, Immediate
Hypersensitivity
Immune System Diseases

ClinicalTrials.gov processed this record on July 26, 2014