A Study Using L5 as a Risk Factor of Cardiovascular (CV) Disease in Chronic Renal and Dialytic Patients

The recruitment status of this study is unknown because the information has not been verified recently.
Verified November 2010 by China Medical University Hospital.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
China Medical University Hospital
ClinicalTrials.gov Identifier:
NCT01236820
First received: November 5, 2010
Last updated: November 8, 2010
Last verified: November 2010
  Purpose

The purpose of this study is to determine whether L5, one of the Low Density Lipoproteins, is an effective predicting factor for cardiovascular disease in chronic renal and hemodialytic patients.


Condition
Cardiovascular Disease
Chronic Kidney Disease Patients
Hemodialytic Patients
High LDL Level
High L5 Level

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: L5 as a Risk Factor of Cardiovascular Disease in Chronic Kidney Disease and Dialysis Patients

Resource links provided by NLM:


Further study details as provided by China Medical University Hospital:

Biospecimen Retention:   Samples Without DNA

Blood


Estimated Enrollment: 48
Study Start Date: September 2010
Groups/Cohorts
Normal
Healthy population
CKD Patients
Chronic Kidney Disease, in Stage III-V
HD patients
End-stage renal disease patients undergoing hemodialysis

Detailed Description:

Cardiovascular disease (CVD) is the most important cause of death of chronic kidney disease (CKD) and hemodialysis (HD) patients. Low Density Lipoprotein (LDL) is an essential indicator of CVD.The higher the plasma LDL level, the higher the risk of CVD. LDL is a heterogenous substance composed of different mass and size. Oxidized LDL (oxLDL) is the oxidation product of LDL and is the most important component of LDL associated with CVD. The oxLDL is mostly trapped within tissue and not easily to be detected from blood. L5 iw a kind of electronegative LDL and is associated with CVD in smokers and diabetic patients, even if these patients have normal plasma LDL. Uremia patients have lipid profile different from that of general people,while HD Patients have lower LDL and CKD patients have LDL higher than that of general population. Thus LDL plasma level cannot fully explain the high risk of CVD in CKD and HD patients. As patients with normal LDL but high L5 are prone to have CVD, we suspect there might be association of L5 with CVD in both CKD and HD patients.

  Eligibility

Ages Eligible for Study:   20 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Residents in Taiwan, mostly in Taichung area

Criteria

Inclusion Criteria:

  • clinical diagnosis of CKD
  • clinical diagnosis of HD

Exclusion Criteria:

  • N/A
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01236820

Contacts
Contact: Chiz-Tzung Chang, Ph.D. 886-4-22052121 ext 2902 D19863@mail.cmuh.org.tw
Contact: Chiu-Ching Huang, MD 886-4-22052121 ext 2902 cch@mail.cmuh.org.tw

Locations
Taiwan
China Medical University Hospital Recruiting
Taichung City, Taiwan, 404
Contact: Chiu-Ching Huang, MD    886-4-22052121 ext 2902    cch@mail.cmuh.org.tw   
Contact: Chiz-Tzung Chang, MD, Ph.D.    886-4-22052121 ext 2902    D19863@mail.cmuh.org.tw   
Principal Investigator: Chiu-Ching Huang, MD         
Sponsors and Collaborators
China Medical University Hospital
  More Information

No publications provided

Responsible Party: Chiu-Ching Huang, China Medical University Hospital
ClinicalTrials.gov Identifier: NCT01236820     History of Changes
Other Study ID Numbers: CTCHANG001
Study First Received: November 5, 2010
Last Updated: November 8, 2010
Health Authority: Taiwan: Department of Health

Keywords provided by China Medical University Hospital:
L5
LDL
Cardiovascular disease
Chronic kidney disease
Hemodialysis

Additional relevant MeSH terms:
Cardiovascular Diseases
Kidney Diseases
Renal Insufficiency, Chronic
Kidney Failure, Chronic
Urologic Diseases
Renal Insufficiency

ClinicalTrials.gov processed this record on July 10, 2014