RNA Biomarkers in Tissue Samples From Infants With Acute Myeloid Leukemia
Recruitment status was Active, not recruiting
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in RNA and identify biomarkers related to cancer.
PURPOSE: This research study is studying RNA biomarkers in tissue samples from infants with acute myeloid leukemia.
Genetic: RNA analysis
Genetic: nucleic acid sequencing
Genetic: reverse transcriptase-polymerase chain reaction
Other: laboratory biomarker analysis
|Official Title:||SCOR in Targeted Therapies for Infant Leukemias Project 4: MicroRNA Sequencing of Infant AML|
- Sequence of the microRNAs present in 20 infant acute myeloid leukemia (AML) samples [ Designated as safety issue: No ]
- Comparison of microRNAs present in infant AML samples to infant acute lymphoblastic leukemia samples to identify lineage- and translocation-specific microRNAs [ Designated as safety issue: No ]
|Study Start Date:||October 2010|
|Estimated Primary Completion Date:||January 2011 (Final data collection date for primary outcome measure)|
- Sequence the microRNAs present in 20 infant AML samples as a pilot study.
- Compare microRNAs present in infant AML samples to infant ALL samples that are being concurrently sequenced in a separate study to identify lineage- and translocation-specific microRNAs.
OUTLINE: This is a multicenter study.
Previously collected cryopreserved cells from diagnosis are sequenced using reverse transcriptase-PCR.
|Principal Investigator:||Michael Cleary, MD||Stanford University|