Distribution of Regional Lung Function by Vibration Response Imaging
Assessment of regional contribution of different areas of the lung to its integrated function is often required, such as prior to lung resection in the presence of tumor or emphysema. This assessment is derived from the proportion of zonal radionuclear perfusion or ventilation. The investigators hypothesized that lung VRI may provide an alternative approach to assess regional lung function.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Distribution of Regional Lung Function, as Determined by the Vibration Response Image Generated by the VRI-2000 System as Compared With Standard Radio-nuclear Method|
- Comparison of regional lung vibration energy with regional lung function [ Designated as safety issue: No ]To map regional lung vibration energy in patients with emphysema by using the lung image generated by the VRI system and compare findings to distibution of perfusion and ventilation in standard V/Q scans
- Correlation of vibration lung sound energy with regional lung functions by V/Q scan [ Designated as safety issue: No ]Evaluate if the regional vibration energy is correlated with regional lung functions, as assessed by V/Q scan
|Study Start Date:||February 2004|
|Study Completion Date:||January 2006|
|Primary Completion Date:||January 2006 (Final data collection date for primary outcome measure)|
Patients diagnosed with COPD, by the pulmonologist at the institute,who are referred to undergo ventilation/perfusion scans.
Other: Observational study - no intervention
Observational study - no intervention. Patients underwent VRI recordings and routine V/Q scan.
Patients diagnosed with moderate-to-severe COPD by lung function studies and clinical evaluation presented in stable clinical condition and were evaluated by lung sound recordings and quantitative V/Q lung scintigraphy. Regional signals (percentage of lung sounds) for left and right lungs were compared with the corresponding regional count percentages of each radionuclide scan, by V/Q scan regions of interest.