Clinical Trial Comparing Continuous Versus Intermittent Hemodialysis in ICU Patients (CONVINT)

This study has been completed.
Sponsor:
Information provided by:
Charite University, Berlin, Germany
ClinicalTrials.gov Identifier:
NCT01228123
First received: October 25, 2010
Last updated: May 23, 2011
Last verified: July 2010
  Purpose

The mortality of acute renal failure (ARF) remains to be high (around 60-70%) despite manifold improvements in ICU care. At present, it is not clear if the method chosen for renal replacement therapy, i.e. intermittent haemodialysis (IHD) or continuous haemofiltration (CVVH), might impact on the outcome of these patients. For this purpose, a prospective randomised clinical study of the effect of continuous versus intermittent renal replacement therapy on the mortality and outcome of acute renal failure will be performed.


Condition Intervention Phase
Acute Renal Failure
Other: RRT for acute kidney failure using the CVVH method
Other: RRT for acute kidney failure using the IHD (intermittent HD)
Phase 2
Phase 3

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Diagnostic
Official Title: Prospective Randomised Clinical Trial of the Effect of Continuous Versus Intermittent Renal Replacement Therapy on the Mortality and Outcome of Acute Renal Failure in ICU Patients

Resource links provided by NLM:


Further study details as provided by Charite University, Berlin, Germany:

Primary Outcome Measures:
  • Survival at 2 weeks after RRT [ Time Frame: 2 weeks after RRT in follow-up ] [ Designated as safety issue: No ]

Enrollment: 252
Study Start Date: January 2002
Study Completion Date: January 2008
Primary Completion Date: October 2007 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: CVVH arm Other: RRT for acute kidney failure using the CVVH method
patients randomized to receive CVVH
Other Name: does not apply
Active Comparator: IHD arm Other: RRT for acute kidney failure using the IHD (intermittent HD)
patients randomized to receive IHD
Other Name: does not apply

Detailed Description:

please see above

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • all ICU patients requiring renal replacement therapy

Exclusion Criteria:

  • patient denies informed consent
  • patient not requiring intensive care therapy
  • kidney transplanted patients
  • chronic renal failure (serum creatinine > 3mg/dl)
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01228123

Locations
Germany
Charite University Medicine
Berlin, Germany, 13353
Sponsors and Collaborators
Charite University, Berlin, Germany
Investigators
Principal Investigator: Achim Joerres, MD Charite University Medicine
  More Information

No publications provided

Responsible Party: investigator initiated trial (see adress below), Charite University Medicine
ClinicalTrials.gov Identifier: NCT01228123     History of Changes
Other Study ID Numbers: CONVINT
Study First Received: October 25, 2010
Last Updated: May 23, 2011
Health Authority: Germany: Federal Institute for Drugs and Medical Devices

Additional relevant MeSH terms:
Acute Kidney Injury
Renal Insufficiency
Kidney Diseases
Urologic Diseases

ClinicalTrials.gov processed this record on July 23, 2014