Study of Gene Associations and Infertility
The purpose of this this study is to use DNA screening strategies to identify genes and localize genomic regions that are differentially expressed in patients with infertility to further understand the genetic basis for reproductive competence.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Genes and Gene Polymorphisms Associated With Infertility: Utilization of DNA Characteristics to Better Understand Reproductive Competence|
- Number of retrieved oocytes [ Time Frame: 1 month ] [ Designated as safety issue: No ]
- Fertilization rate [ Time Frame: 1 month ] [ Designated as safety issue: No ]Number of oocytes that are fertilized
- Number of available embryos [ Time Frame: 1 month ] [ Designated as safety issue: No ]Number of embryos that are available for transfer on day 3 or day 5
- Pregnancy rates [ Time Frame: 1 year ] [ Designated as safety issue: No ]Clinical pregnancy rates (detection of pregnancy hormone bHCG in blood) and delivery rates.
Biospecimen Retention: Samples With DNA
whole blood serum, follicular fluid and sperm
|Study Start Date:||February 2006|
|Estimated Study Completion Date:||December 2016|
|Estimated Primary Completion Date:||December 2015 (Final data collection date for primary outcome measure)|
Patients undegoing infertility treatment
Male and female patients undergoing infertility treatment
Experimental strategies seek to discover small variants in DNA sequences, which are associated with certain infertility parameters. The alleles being analyzed in in vitro fertilization (IVF) population are sought to be associated with functional differences in the expression of the gene product that are then mechanistically linked to infertility.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01223092
|United States, New Jersey|
|Reproductive Medicine Associates of New Jersey|
|Morristown, New Jersey, United States, 07960|
|Principal Investigator:||Richard T Scott, MD||Reproductive Medicine Associates of New Jersey|
|Study Director:||Nathan R Treff, PhD||Reproductive Medicine Associates of New Jersey|