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Development of Bone Grafts Using Adipose Derived Stem Cells and Different Scaffolds

This study is currently recruiting participants.
Verified February 2012 by University of Zurich
Sponsor:
Information provided by (Responsible Party):
University of Zurich
ClinicalTrials.gov Identifier:
NCT01218945
First received: September 29, 2010
Last updated: February 23, 2012
Last verified: February 2012
History of Changes
  Purpose

The repair of large osseous defects remains still unsolved. Aim of this study is to isolate and cultivate fat-derived progenitor cells and differentiation into osteoblasts. Therefore, our research idea is to pre-engineer large synthetic bone grafts and study the vascularization process in vivo.


Condition Intervention
Overweight
 Procedure: Cell Culture

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Development of Bone Grafts Using Adipose Derived Stem Cells and Different Scaffolds: Impact of Pre-engineered Capillaries in Critical Size Grafts

Resource links provided by NLM:

MedlinePlus related topics: Bone Grafts
U.S. FDA Resources

Further study details as provided by University of Zurich:

Biospecimen Retention:   Samples With DNA

Human adipose-derived stem cells from human fat


Estimated Enrollment: 100
Study Start Date: November 2009
Estimated Study Completion Date: August 2012
Estimated Primary Completion Date: August 2012 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
Fat Removal
Patients undergoing surgical fat removal
 Procedure: Cell Culture
Aim of this study is to isolate and cultivate fat-derived progenitor cells and differentiation into osteoblasts. Therefore, our research idea is to pre-engineer large synthetic bone grafts and study the vascularization process in vivo.

  Eligibility

Ages Eligible for Study:   18 Years to 70 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Patients admitted for reconstructive surgery

Criteria

Inclusion criteria:

  • German-speaking patients aged 18-70 admitted to the Clinic of Reconstructive surgery for reconstructive surgery and fat-excision.

Exclusion criteria:

  • Drug-abuse, neoplasia and metabolic disorders
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01218945

Contacts
Contact: Maurizio Calcagni, MD +41 (0)44 255 11 11 maurizio.calcagni@usz.ch

Locations
Switzerland
University Hospital Zurich, Clinic of Reconstructive Surgery Recruiting
Zurich, ZH, Switzerland, 8091
Contact: Maurizio Calcagni         maurizio.calcagni@usz.ch    
Contact: Guido Wanner         guido.wanner@usz.ch    
Sponsors and Collaborators
University of Zurich
Investigators
Principal Investigator: 01 Studienregister MasterAdmins, MD University Hospital Zurich, Clinic of Reconstructive Surgery
  More Information

No publications provided

Responsible Party: University of Zurich
ClinicalTrials.gov Identifier: NCT01218945     History of Changes
Other Study ID Numbers: Bone-ZH09
Study First Received: September 29, 2010
Last Updated: February 23, 2012
Health Authority: Switzerland: Swissmedic

Additional relevant MeSH terms:
Overweight
Body Weight
Signs and Symptoms

ClinicalTrials.gov processed this record on May 22, 2013