Involvement of Translation Initiation Factors in the Immune Response in the Elderly

The recruitment status of this study is unknown because the information has not been verified recently.
Verified March 2012 by Meir Medical Center.
Recruitment status was  Recruiting
Sponsor:
Information provided by (Responsible Party):
Meir Medical Center
ClinicalTrials.gov Identifier:
NCT01215604
First received: October 5, 2010
Last updated: March 16, 2012
Last verified: March 2012
  Purpose

The investigators propose that the translation initiation factors eIF4E and eIF4GI may be involved in resolution of acute inflammation (regardless of age). Furthermore, the investigators suggest that differences in translation initiation factors state of activation may contribute to inflammation. Finally, the investigators hypothesize that differences in translation initiation factors state of activation may underlie the immune compromised state of the very elderly affording additional explanation for the heightened morbidity from infection in this group.

In the current study the investigators aim to test these hypotheses by measuring the levels of eIF4E and eIF4G, their regulators, and targets in elderly (65-84yrs) and very elderly (85yrs<) patients hospitalized at Meir hospital for acute infection and after their recovery (detailed in study design).


Condition
Elderly Patient
Infection

Study Type: Observational
Study Design: Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Characterization of the Involvement of Translation Initiation Factors in the Immune Response to Acute Infection in the Elderly and Very Elderly

Further study details as provided by Meir Medical Center:

Biospecimen Retention:   Samples With DNA

Blood samples of elderly patients diagnosed with acute infection will be collected at admittance to Meir hospital and on recovery (24-48 hours without fever and leukocytosis)


Estimated Enrollment: 40
Study Start Date: October 2010
Estimated Study Completion Date: October 2012
Primary Completion Date: October 2011 (Final data collection date for primary outcome measure)
  Eligibility

Ages Eligible for Study:   65 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

patient aged >65 years admitted to internal medicine or geriatric departments due to acute infection with fever and leukocytosis.

Criteria

Inclusion Criteria:

  • elderly patients (65<)
  • hospitalized for acute infection (fever 38c<, leukocytosis)

Exclusion Criteria:

  • patients with dementia who can not sign informed consent of institutional Helsinki committee
  • patient with active cancer with active chemotherapy treatment
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01215604

Locations
Israel
Meir Medical Center Recruiting
Kfar Sava, Israel
Contact: Racheli Heffez, MD    972-9-7472181    rachelhe2@clalit.org.il   
Principal Investigator: rachel Heffez Ayzenfeld, MD         
Sponsors and Collaborators
Meir Medical Center
Investigators
Principal Investigator: Rachel Heffez Ayzenfeld, MD Meir Medical Center
  More Information

No publications provided

Responsible Party: Meir Medical Center
ClinicalTrials.gov Identifier: NCT01215604     History of Changes
Other Study ID Numbers: MMC10156-2010CTIL
Study First Received: October 5, 2010
Last Updated: March 16, 2012
Health Authority: Israel: The Israel National Institute for Health Policy Research and Health Services Research

Keywords provided by Meir Medical Center:
elderly patients
acute infection
translation initiation factors
eIF4E
eIF4G

Additional relevant MeSH terms:
Infection
Communicable Diseases

ClinicalTrials.gov processed this record on September 22, 2014