Involvement of Translation Initiation Factors in the Immune Response in the Elderly
The investigators propose that the translation initiation factors eIF4E and eIF4GI may be involved in resolution of acute inflammation (regardless of age). Furthermore, the investigators suggest that differences in translation initiation factors state of activation may contribute to inflammation. Finally, the investigators hypothesize that differences in translation initiation factors state of activation may underlie the immune compromised state of the very elderly affording additional explanation for the heightened morbidity from infection in this group.
In the current study the investigators aim to test these hypotheses by measuring the levels of eIF4E and eIF4G, their regulators, and targets in elderly (65-84yrs) and very elderly (85yrs<) patients hospitalized at Meir hospital for acute infection and after their recovery (detailed in study design).
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||Characterization of the Involvement of Translation Initiation Factors in the Immune Response to Acute Infection in the Elderly and Very Elderly|
Blood samples of elderly patients diagnosed with acute infection will be collected at admittance to Meir hospital and on recovery (24-48 hours without fever and leukocytosis)
|Study Start Date:||October 2010|
|Estimated Study Completion Date:||October 2012|
|Primary Completion Date:||October 2011 (Final data collection date for primary outcome measure)|
|Meir Medical Center||Recruiting|
|Kfar Sava, Israel|
|Contact: Racheli Heffez, MD 972-9-7472181 email@example.com|
|Principal Investigator: rachel Heffez Ayzenfeld, MD|
|Principal Investigator:||Rachel Heffez Ayzenfeld, MD||Meir Medical Center|