Retinal Vascular Reactivity in Subjects With Newly Diagnosed Glaucoma Before and After Selective Laser Trabeculoplasty
Recruitment status was Recruiting
The purpose of this study is to assess retinal blood flow and vascular reactivity in patients with newly diagnosed primary open angle glaucoma pre- and post-primary Selective Laser Trabeculoplasty(SLT). Canon Laser Blood Flowmeter will be used for the assessment of retinal blood flow.
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||Retinal Vascular Reactivity in Response to Isoxic Hypercapnia in Subjects With Newly Diagnosed Glaucoma|
- blood flow [ Time Frame: before and two-week after SLT ] [ Designated as safety issue: Yes ]The Canon Laser Blood Flowmetry will be used to assess the retinal blood flow.
- Intraocuclar pressure [ Time Frame: before and two-week after SLT ] [ Designated as safety issue: Yes ]Intraocular pressure (IOP) will be measured by Goldmann applanation tonometry.
|Study Start Date:||November 2008|
|Estimated Primary Completion Date:||November 2011 (Final data collection date for primary outcome measure)|
untreated glaucoma patients
We will evaluate the blood flow before and after Selective Laser Trabeculoplasty in patients with primary open angel glaucoma.
Procedure: Selective Laser Trabeculoplasty
Patient will have selective laser trabeculoplasty as the first treatment for glaucoma. This treatment will be dictated clinically, since we do not assign the interventions.
We previously found that vascular reactivity improved after short term treatment with dorzolamide drops. It is not clear whether this improvement was a direct effect of the medication or secondary effect of the decrease in IOP. We would like to see the change of vascular reactivity before and after SLT, which will decrease the intraocular pressure without pharmacologic effect.
|Contact: Tien Wongfirstname.lastname@example.org|
|Toronto Western Hospital||Recruiting|
|Toronto, Ontario, Canada, M5T2S8|
|Contact: Tien Wong 416-603-5694 email@example.com|
|Principal Investigator:||Chris Hudson, PhD||University of Toronto|