Ketamine for Low Mood States in the ER
The investigators hope to see if a commonly used drug such as ketamine could help depressed ER patients feel better and improve their mood quickly.
|Study Design:||Endpoint Classification: Safety/Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Low Dose Ketamine for Low Mood States: An Emergency Department Feasibility Study for Depressed Patients|
- Montgomery Asberg Depression Rating Scale (MADRS) [ Time Frame: 40, 80, 120, 240 minutes after administration of drug ] [ Designated as safety issue: No ]The MADRS measures mood (depression) and item 10 measures suicide ideation.
- recruitment success and retention of subjects in the ER [ Time Frame: initial recruitment of eligible subjects in the ER and for two weeks after administration of drug ] [ Designated as safety issue: No ]All patient subjects are admitted and we will follow them in the hospital and for 2 weeks after hospital discharge.
|Study Start Date:||April 2010|
|Study Completion Date:||December 2010|
|Primary Completion Date:||December 2010 (Final data collection date for primary outcome measure)|
Rapid-onset antidepressants could have important clinical impact if their benefits extended to Emergency Department (ED) patients. We hope to explore the preliminary feasibility, tolerability and efficacy of single-dose, intravenous (IV) ketamine in depressed ED patients who presented with suicide ideation (SI).
Please refer to this study by its ClinicalTrials.gov identifier: NCT01209845
|United States, Connecticut|
|Yale New Haven Hospital Emergency Department|
|New Haven, Connecticut, United States, 06519|
|Principal Investigator:||Gregory L Larkin, MD||Yale University School of Medicine, Department of Emergency Medicine|