Prognostic Biomarkers in Patients With Endometrial Cancer
Recruitment status was Not yet recruiting
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This research study is studying prognostic biomarkers in tissue samples from patients with endometrial cancer.
Genetic: DNA analysis
Genetic: mutation analysis
Other: laboratory biomarker analysis
|Official Title:||Validating the Prognostic Role of ATR Mutation in Patients With Endometrioid Endometrial Cancer|
- Overall survival [ Designated as safety issue: No ]
- Cancer-specific survival [ Designated as safety issue: No ]
- Disease-free survival [ Designated as safety issue: No ]
|Study Start Date:||October 2010|
|Estimated Primary Completion Date:||November 2010 (Final data collection date for primary outcome measure)|
- To validate the clinicopathologic associations and prognostic significance of ATR mutation in endometrioid endometrial cancer cases with defective DNA mismatch repair.
OUTLINE: This is a multicenter study.
DNA extracted from previously collected tumor samples is analyzed to validate the clinicopathologic associations and prognostic significance of ATR mutation.
|Principal Investigator:||Israel Zighelboim, MD||Washington University Siteman Cancer Center|