Yoga and Exercise in Psychosis (YEP)
Recruitment status was Recruiting
The current study aims to evaluate the impacts of Yoga and Physical Exercise on the structural change to the hippocampus, functional change in Default Mode Network (DMN), neure-cognitive function, and clinical symptoms in psychosis. A total of 120 female subjects who aging from 18-55 years old, and diagnosed with psychosis within the past 5 years, will be randomized into 3 groups: 1) Yoga therapy, 2) Physical exercise, and 3) a control group, made up of individuals in the yoga or exercise waitlist. All groups will try to be kept consistent with their medication with no more than 25% change in their entry level dosage for at least six weeks. This study will assess the physical fitness, body-perception, drug adherence, and medication side effects in addition to the outcome domains of structural and functional Magnetic Resonance Imaging (MRI), neure-cognitive function, clinical symptoms and quality of life.
|Study Design:||Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Treatment
|Official Title:||The Impacts of Yoga and Exercise on Neure-cognitive Function and Symptoms in Early Psychosis - A Single Blind Randomized Controlled Clinical Trial|
- Structural and Functional Magnetic Resonance Imaging [ Time Frame: at 12 weeks ] [ Designated as safety issue: No ]
- Cognitive function [ Time Frame: at 12 weeks ] [ Designated as safety issue: No ]
- Clinical symptoms [ Time Frame: at 12 weeks ] [ Designated as safety issue: No ]
- Side effect of psychotropic medications with the Udvalg for Kliniske Undersøgelser (UKU) [ Time Frame: at 12 weeks ] [ Designated as safety issue: Yes ]
- Fitness measure [ Time Frame: at 12 weeks ] [ Designated as safety issue: No ]
- Quality of life [ Time Frame: at 12 weeks ] [ Designated as safety issue: No ]
|Study Start Date:||September 2010|
|Estimated Study Completion Date:||December 2013|
|Estimated Primary Completion Date:||December 2013 (Final data collection date for primary outcome measure)|
Experimental: Yoga therapy
Yoga therapy includes breathing control (5-10minutes), Posture(40-45minutes), and relaxation (5-10minutes).
Behavioral: Yoga therapy
Yoga therapy, including breathing control, postures, and relaxation. 60 minutes for each session, 3 sessions weekly for 12 weeks.
Experimental: Physical Exercise
Physical exercise includes cycling, walking, and/or resistance training
Behavioral: Physical exercise
cycling, walking, and/or resistance training, 45-55 minutes for each session, 3 sessions weekly for 12 weeks.
No Intervention: Waiting list
Patients in waiting list will be acted as control group.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01207219
|Contact: Jessie, JX Lin, Masterfirstname.lastname@example.org|
|Department of Psychiatry, LKS Faculty of Medicine, the University of Hong Kong||Recruiting|
|Hong Kong, Hong Kong, 852|
|Contact: Jessie, JX Lin, Master +85222553064 email@example.com|
|Sub-Investigator: Eric Chen, Prof.|
|Principal Investigator:||Jessie, JX Lin, Master||Department of Psychiatry, the University of Hong Kong|