Confocal Laser Micro-endoscopy in Chronic Obstructive Pulmonary Disease (COPD) and Lung Transplant Recipients
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Purpose
Aspects of confocal laser micro-endoscopy (CLME) and morphometry in chronic obstructive pulmonary disease (COPD) and lung transplant recipients is described and will be correlated with clinical findings in order to described small airway remodelling in these patients.
| Condition |
|---|
|
Lung Transplantation Chronic Obstructive Pulmonary Disease |
| Study Type: | Observational |
| Study Design: | Observational Model: Case Control Time Perspective: Prospective |
| Official Title: | Confocal Laser Micro-endoscopy: New Insights in COPD and Lung Transplant Recipients |
| Estimated Enrollment: | 100 |
| Study Start Date: | September 2010 |
| Groups/Cohorts |
|---|
|
COPD
COPD Gold class 1-4
|
|
Transplant
Lung transplant recipients
|
|
Control
Patients with normal spirometric data
|
Detailed Description:
In early phases of COPD, changes in small airway characteristics may develop. Elastin decay and matrix remodelling could be responsible for these changes. Using CLME changes of in the bronchiolar wall and alveolar ducts can be visualized, described and measured.
In lung transplant recipients, CMLE will be performed to distinguish characteristics of distal airways in stabile patient in contrast to patients with bronchiolitis obliterans syndrome.
In both groups data will be correlated with CT findings, pulmonary function tests and anatomopathological results.
Eligibility| Ages Eligible for Study: | 18 Years to 80 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Probability Sample |
Patients referred for a bronchoscopic procedure will be asked to undergo CLME. 3 pools will be made: COPD patients according to their pulmonary function test, lung transplant recipients and patients with normal spirometric results. In all groups the difference between active smokers and no-smokers will be made.
Inclusion Criteria:
- referral for bronchoscopic investigation/sampling
- informed consent signed
- recent spirometric data
Exclusion Criteria:
- sedated and/or ventilated patients
- patients on ICU
- patients under oral anticoagulation
- co-existing lung disease
- acute infectious pulmonary disease
Contacts and Locations| Contact: Jonas Yserbyt, MD | +3216340442 | jonas.yserbyt@uzleuven.be |
| Contact: Christophe Dooms, PhD | +3216332211 | christophe.dooms@uzleuven.be |
| Belgium | |
| University Hospitals Leuven | Recruiting |
| Leuven, Belgium, 3000 | |
| Contact: jonas Yserbyt, MD +3216340442 jonas.yserbyt@uzleuven.be | |
| Principal Investigator: | Jonas Yserbyt, MD | University Hospitals Leuven |
| Principal Investigator: | Chistophe Dooms, MD, PhD | University Hospitals Leuven |
| Study Chair: | Marc Decramer, MD, PhD | University Hospitals Leuven |
| Study Chair: | Geert Verleden, Md, PhD | University Hospitals Leuven |
| Study Chair: | Wim Janssens, MD, PhD | University Hospitals Leuven |
More Information
No publications provided
| Responsible Party: | Marc Decramer, Prof. Dr., Katholieke Universiteit Leuven |
| ClinicalTrials.gov Identifier: | NCT01204970 History of Changes |
| Other Study ID Numbers: | B32220109292 |
| Study First Received: | September 17, 2010 |
| Last Updated: | August 1, 2012 |
| Health Authority: | Belgium: Institutional Review Board |
Keywords provided by Katholieke Universiteit Leuven:
|
Confocal Laser Scanning Microendoscopy Small airways COPD Lung transplantation |
Additional relevant MeSH terms:
|
Lung Diseases Respiration Disorders Pulmonary Disease, Chronic Obstructive Lung Diseases, Obstructive Respiratory Tract Diseases |
ClinicalTrials.gov processed this record on May 19, 2013