Additional Benefit of Cilostazol to Dual Antiplatelet Therapy After Biolimus-eluting Stent Implantation (ABCD)

This study has been completed.
Sponsor:
Collaborator:
Cardiovascular Research Center
Information provided by (Responsible Party):
Yoon Junghan, Yonsei University
ClinicalTrials.gov Identifier:
NCT01192724
First received: August 31, 2010
Last updated: January 9, 2013
Last verified: January 2013
  Purpose

Because there is limited data about long-term efficacy and safety about short-term use of cilostazol adding to dual antiplatelet therapy in patients with long or multivessel coronary artery disease after 2nd generation DES implantation, especially in biodegradable polymer stent, the investigators will evaluate whether a 3-month use of cilostazol in addition to dual antiplatelet therapy effectively reduces clinical adverse outcome at 1 year in subject with long or multivessel coronary artery disease after biolimus-eluting stent implantation.


Condition Intervention Phase
Coronary Artery Disease
Drug: Cilostazol
Drug: Aspirin
Drug: Clopidogrel
Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety/Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: A Trial of Evaluating Additional Benefit of Cilostazol to Dual Antiplatelet Therapy in Patients With Long or Multi-vessel Coronary Artery Disease Underwent Biolimus-Eluting Stent Implantation

Resource links provided by NLM:


Further study details as provided by Yonsei University:

Primary Outcome Measures:
  • Device-oriented composite [ Time Frame: One year ] [ Designated as safety issue: No ]
    Device-oriented composite was defined as a composite of cardiac death, MI (not clearly attributable to a non-target vessel), and clinically indicated target lesion revascularization (TLR).


Secondary Outcome Measures:
  • Patient-oriented composite [ Time Frame: One year ] [ Designated as safety issue: Yes ]
    Patient-oriented composite was defined as a composite of all-cause mortality, any MI (includes non-target vessel territory), and any repeat revascularization (includes all target and non-target vessel).

  • Each component of device- and patient-oriented composite [ Time Frame: One year ] [ Designated as safety issue: No ]
    All-cause mortality, cardiac death, any myocardial infarction (MI), MI (not clearly attributable to a non-target vessel), clinically indicated target lesion revascularization (TLR), and any repeat revascularization (includes all target and non-target vessel)

  • Academic Research Consortium (ARC) defined stent thrombosis [ Time Frame: One year ] [ Designated as safety issue: No ]
    definite, probable, and possible stent thrombosis / acute, subacute, and late stent thrombosis

  • Safety assessments [ Time Frame: One year ] [ Designated as safety issue: Yes ]
    Safety assessments will be performed for bleeding complication according to Thrombolysis In Myocardial Infarction (TIMI) criteria, medication compliance, side effect of drug, and heart rate.


Enrollment: 630
Study Start Date: March 2010
Study Completion Date: December 2012
Primary Completion Date: December 2012 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Triple antiplatelet therapy (TAPT) group
3-month use of cilostazol in addition to dual antiplatelet agent
Drug: Cilostazol
100 mg BID, for 3 months
Other Name: pletaal
Drug: Aspirin
Aspirin 100 mg QD, for 1 year
Other Names:
  • Aspirin protect
  • Astrix
  • Baby rhonal
Drug: Clopidogrel
Clopidogrel 75 mg QD, for 1 year
Other Names:
  • Plavix
  • Plavitor
  • Platless
Active Comparator: Dual antiplatelet therapy (DAPT) group
Aspirin and clopidogrel (dual antiplatelet therapy, DAPT) for 1 year
Drug: Aspirin
Aspirin 100 mg QD, for 1 year
Other Names:
  • Aspirin protect
  • Astrix
  • Baby rhonal
Drug: Clopidogrel
Clopidogrel 75 mg QD, for 1 year
Other Names:
  • Plavix
  • Plavitor
  • Platless

Detailed Description:

Previous randomized trials have shown the efficacy of drug-eluting stent (DES) such as sirolimus-eluting stent (CYPHERTM, Cordis, Warren, NJ, USA), paclitaxel-eluting stent (TAXUSTM, BostonScientific, Natick, MA, USA), and zotarolimus-eluting stent (Endeavor,Medtronic,Minneapolis, MN, USA) over bare metal stents (BMS) in reducing neointimal hyperplasia, late luminal loss, and angiographic restenosis leading to decreased target lesion revascularization.1-4 In addition, Among patients with off-label indications, the use of DESs reduced a rate of repeat revascularization without increasing the risk of death or myocardial infarction, as compared with bare-metal stents.5 But, compared with on-label use, off-label use of DESs is associated with a higher rate of adverse outcomes such as death, myocardial infarction and target vessel revascularization. Furthermore, stent thrombosis (ST) occurred predominantly in patients who underwent off-label DES implantation.6 It is known that the risk of adverse cardiac events and ST after DES implantation is related to stent length.7 Cilostazol is a potent phosphodiesterase III inhibitor preventing the hydrolysis of cAMP in platelets and vascular smooth muscle cell. The novel mechanism of action of cilostazol reduces the number of circulating, partially activated, or preconditioned platelets, by reducing the surface expression of adhesive molecules in endothelial cells interacting with circulating platelets. The agent also directly inhibits platelet aggregation induced by a variety of stimuli, including arachidonic acid, ADP, collagen, thrombin, and high shear stress.8 In current guidelines, a 12-month duration of dual antiplatelet therapy with aspirin and clopidogrel is recommended after DES implantation.9 But, recent meta-analyses showed a potential benefit of cilostazol in addition to dual antiplatelet therapy in reducing angiographic restenosis and improved clinical outcomes after BMS or DES implantation.10, 11 Actually, additional cilostazol to dual antiplatelet therapy showed reduced restenosis and late loss in patients with long coronary lesion and diabetes with multivessel coronary artery disease and it also showed beneficial effect on stent thrombosis after DES implantation.12-14 Although most studies showed no difference in bleeding according to additional cilostazol to dual antiplatelet therapy, the rate of early cessation of cilostazol due to adverse effect including headache, palpitation, skin rash and hepatic dysfunction was about 15%.12-14 Because of relatively higher side effect rate and no definitive duration of addition cilostazol use, we expect that cilostazol with short duration can be easily accepted to patient. Although almost studies about cilostazol after stent implantation used a 6- month duration of cilostazol, one study showed that use of cilostazol for 3 months after percutaneous transluminal coronary balloon angioplasty reduced restenosis and revascularization, as compared with use of aspirin.15 So, we expect a 3-month use of additional cilostazol to dual antiplatelet therapy can reduce the adverse outcome and ST after stent implantation without increasing early cessation of cilostazol.

The BioMatrixTM stent system (Biosensors Interventional Technologies Pte., Ltd, Singapore) consist of a stainless steel, quadrature-link design, balloon expandable S-StentTM, and a polylactic acid (PLA) polymer and BiolimusA9® coating mounted on a low-profile delivery catheter.16, 17 It is expected that abluminal biodegradable coating of BioMatrixTM stent can lead to more targeted drug release, reduced systemic exposure and early BMS-like endothelial coverage.18 The first-in-man, randomized controlled SEALTH I trial demonstrate higher efficacy of BioMatrixTM stent by showing lower late lumen loss and in-stent restenosis as compared with BMS, S-stent at 6-month follow-up.19 In LEADERS trial, BioMatrixTM stent showed similar efficacy and safety as compared with sirolimus-eluting stent in patients with chronic stable coronary artery disease and acute coronary syndromes.20 But significantly lower uncovered and malapposed struts was detected by optical coherence tomography study.21 This means more complete coverage of struts and we can expect lower late ST after BioMatrixTM stent implantation.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion criteria:

  • Age > 18 years.
  • Subject is able to verbally confirm understandings of risks, benefits and treatment alternatives of receiving the BioMatrix® and he/she or his/her legally authorized representative provides written informed consent prior to any study related procedure.
  • Subject must have significant coronary artery stenosis (>70% by visual estimate).
  • Subject must have evidence of myocardial ischemia (e.g., stable, unstable angina, recent infarction, acute myocardial infarction, silent ischemia, positive functional study or a reversible changes in the ECG consistent with ischemia).
  • Target lesion(s) located in a native coronary artery with visually estimated diameter of ≥ 2.0 and ≤ 4.24 mm
  • Target lesion(s) amenable for PCI
  • Lesion(s) must have at least 1 of these 2 angiographic features to be eligible
  • Lesion(s) need(s) stent length ≥ 28mm (multiple stents whether are overlapped or not are allowed. No limitation of stent length)
  • Multivessel coronary artery disease that need ≥2 stents regardless of stent length
  • Significant (>70%) lesions in at least two major epicardial vessels (≥ 2.0mm in diameter)
  • Lesion(s) of chronic total occlusion or bifurcation which need ≥ 2 stents can be eligible

Exclusion criteria:

  • The subject has a known hypersensitivity or contraindication to any of the following medications: heparin, aspirin, clopidogrel, biolimus A9, stainless steel, cobalt chromium, contrast media*. (*Subjects with documented sensitivity to contrast media, which can be effectively premedicated with steroid and diphenhydramine may be enrolled. However, those with true anaphylaxis to prior contrast media should not be enrolled.)
  • Systemic (intravenous) biolimus A9 use within 12 months.
  • Female of childbearing potential, unless a recent pregnancy test is negative, who possibly plan to become pregnant any time after enrollment into this study.
  • History of bleeding diathesis or known coagulopathy (including heparin-induced thrombocytopenia), or will refuse blood transfusions.
  • Gastrointestinal or genitourinary bleeding within the prior 3 months, or major surgery within 2 months.
  • Current known current platelet count <100,000 cells/mm3 or Hgb <10 g/dL.
  • An elective surgical procedure is planned that would necessitate interruption of thienopyridines during the first 12 months post enrollment
  • Non-cardiac co-morbid conditions are present with life expectancy <1 year or that may result in protocol non-compliance (per site investigator's medical judgment).
  • Subjects who are actively participating in another drug or device investigational study, which have not completed the primary endpoint follow-up period.
  • Subjects who have received DES implantation in the any coronary artery prior to enrollment
  • Subjects with heart failure, NYHA class III or IV or those with cardiogenic shock. (The degree of left ventricular ejection fraction is not considered as an index of exclusion)
  • Creatinine level > 3.0mg/dL or dependence on dialysis.
  • Severe hepatic dysfunction AST or ALT > 3 times upper normal reference values) except MI-induced elevation
  • Subjects who need antagonist of vitamin K due during study
  • Isolated left main disease (lesion(s) at proximal LAD or LCX lesion that need to cross the left main can be enrolled)
  • Target lesion(s) with ISR
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01192724

Locations
Korea, Republic of
Wonju Christian Hospital
Wonju, Gangwon, Korea, Republic of, 220-050
Sponsors and Collaborators
Yonsei University
Cardiovascular Research Center
Investigators
Principal Investigator: Junghan Yoon, M.D., Ph.D. Wonju College of Medicine, Yonsei University
  More Information

No publications provided

Responsible Party: Yoon Junghan, Junghan Yoon, M.D., Ph.D., Yonsei University
ClinicalTrials.gov Identifier: NCT01192724     History of Changes
Other Study ID Numbers: ABCD
Study First Received: August 31, 2010
Last Updated: January 9, 2013
Health Authority: South Korea: Institutional Review Board

Keywords provided by Yonsei University:
Antiplatelet
Coronary artery diseae
Percutaneous coronary intervention

Additional relevant MeSH terms:
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Heart Diseases
Cardiovascular Diseases
Arteriosclerosis
Arterial Occlusive Diseases
Vascular Diseases
Aspirin
Cilostazol
Clopidogrel
Anti-Inflammatory Agents, Non-Steroidal
Analgesics, Non-Narcotic
Analgesics
Sensory System Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Pharmacologic Actions
Anti-Inflammatory Agents
Therapeutic Uses
Antirheumatic Agents
Fibrinolytic Agents
Fibrin Modulating Agents
Molecular Mechanisms of Pharmacological Action
Cardiovascular Agents
Hematologic Agents
Platelet Aggregation Inhibitors
Cyclooxygenase Inhibitors
Enzyme Inhibitors
Antipyretics

ClinicalTrials.gov processed this record on September 18, 2014