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Safety of Tuberculosis Vaccine, MVA85A, Administered by the Intramuscular Route and the Intradermal Route

This study has been completed.
Sponsor:
Information provided by:
University of Oxford
ClinicalTrials.gov Identifier:
NCT01181856
First received: August 11, 2010
Last updated: March 25, 2011
Last verified: March 2011
  Purpose

This is a phase I study that will compare the safety and immunogenicity of candidate tuberculosis (TB) vaccine MVA85A administered by the intramuscular route and the intradermal route in healthy adult individuals who have been previously vaccinated with Bacillus Calmette-Guerin (BCG).


Condition Intervention Phase
Tuberculosis
Biological: MVA 85A
Phase 1

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Safety Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Prevention
Official Title: Safety and Immunogenicity of Candidate Tuberculosis (TB) Vaccine MVA85A Administered by the Intramuscular Route and the Intradermal Route: a Phase I Randomised Active Controlled Trial

Resource links provided by NLM:


Further study details as provided by University of Oxford:

Primary Outcome Measures:
  • Safety [ Time Frame: 6 months following vaccination ] [ Designated as safety issue: Yes ]
    Safety data in both groups, as assessed by the frequency, incidence, and nature of adverse events (AEs) and serious adverse events (SAEs) during the study. Safety is measured throughout the 6 months follow up period, but specifically on the following days: 2, 7, 14, 28, 56, 84 and 168 and. Blood for safety testing is taken at Days 7 and 28.


Secondary Outcome Measures:
  • Immunogenicity [ Time Frame: 6 months following vaccination ] [ Designated as safety issue: No ]
    Immunogenicity data in both groups. This will be obtained from exploratory immunological laboratory investigations on blood samples taken at screening, and throughout follow up. Immunogenicity is measured throughout the 6 months follow up period, but specifically on the following days: 2, 7, 14, 28, 56, 84 and 168.


Estimated Enrollment: 24
Study Start Date: January 2010
Study Completion Date: January 2011
Primary Completion Date: January 2011 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Group A
Intramuscular immunisation
Biological: MVA 85A
Single injection of 1 x 108 pfu MVA85A
Experimental: Group B
Intradermal immunisation
Biological: MVA 85A
Single injection of 1 x 108 pfu MVA85A

Detailed Description:

We postulate that the intramuscular route is not inferior to the intradermal route of administration of MVA85A in BCG vaccinated adults when evaluated for safety and immunogenicity.

If MVA85A can be given safely by intramuscular route and it is at least equally immunogenic and efficacious in a prime-boost strategy, then it would probably be the preferred route in subsequent phase II and III trials. There are several reasons for this:

  • Reduced pain associated with injection.
  • Reduced local reaction at the injection site.
  • More straightforward procedure; less technically demanding; less time consuming.
  • Easier production and storage of vaccine.
  • Larger volume of vaccine can be given.

Trials of MVA85A to date have established 1 x 10^8 pfu as the optimal dose for intradermal injection in adults. We therefore intend to administer this same dose intramuscularly in order to directly compare the two routes for both safety and immunogenicity. These results will guide future trials in which the intramuscular route, if safe, could be further evaluated at either higher or lower dose depending on immunogenicity at 1 x 10^8 pfu dosage.

  Eligibility

Ages Eligible for Study:   18 Years to 55 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  1. Healthy adult aged 18 - 55 years (both male and female)
  2. Resident in or near Oxford for the duration of the study period
  3. Confirmation of prior vaccination with BCG not less than 3 months prior to projected study vaccination date (by visible BCG scar on examination or written documentation)
  4. Normal medical history and physical examination
  5. Willingness to allow the Investigators to discuss the individual's medical history with their GP
  6. Willingness to use continuous effective barrier contraception for three months after receiving the vaccination (males and females)
  7. Willingness to use effective contraception for the duration of the study period (females only)
  8. Agreement to refrain from blood donation during the course of the study
  9. Give written informed consent
  10. Agreement to allow the Investigator to register volunteer details with a confidential database to prevent concurrent entry into clinical trials
  11. Able and willing (in the Investigator's opinion) to comply with all the study requirements

Exclusion Criteria:

  1. Clinical, radiological, or laboratory evidence of current active TB infection
  2. Laboratory evidence at screening of latent TB infection as indicated by a positive ELISPOT test (greater than 17 sfc/million PBMC) in any ESAT6 peptide or CFP10 peptide poola
  3. Previous vaccination with candidate vaccine MVA85A or another recombinant MVA vaccine
  4. Clinically significant history of skin disorder, allergy, immunodeficiency (including human immunodeficiency virus [HIV]), cancer (except basal cell carcinoma [BCC] or carcinoma in situ [CIS]), cardiovascular disease, respiratory disease, gastrointestinal disease, liver disease, renal disease, endocrine disorder, neurological illness, psychiatric disorder, drug or alcohol abuse
  5. History of serious psychiatric condition
  6. Concurrent oral or systemic steroid medication or the use of other immunosuppressive agents
  7. History of anaphylaxis to vaccination or any allergy likely to be exacerbated by any component of the study vaccine
  8. Any clinically significant abnormality of screening blood or urine tests
  9. Positive hepatitis B surface antigen (HBsAg), hepatitis C virus (HCV) or HIV antibodies
  10. Female currently lactating, confirmed pregnancy or intention to become pregnant during study period
  11. Use of an investigational medicinal product or non-registered drug, live vaccine, or medical device other than the study vaccine for 30 days prior to dosing with the study vaccine, or planned use during the study period
  12. Administration of immunoglobulins and/or any blood products within the three months preceding the planned trial vaccination date
  13. Any other significant disease, disorder, or finding, which, in the opinion of the Investigator, may either put the volunteer at risk or may influence the result of the study or may affect the volunteer's ability to participate in the study
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01181856

Locations
United Kingdom
Centre of Clinical Vaccinology and Tropical Medicine (CCVTM) Churchill Hospital
Oxford, United Kingdom, OX3 7LJ
Sponsors and Collaborators
University of Oxford
Investigators
Principal Investigator: Helen McShane University of Oxford
  More Information

No publications provided by University of Oxford

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: NCT01181856     History of Changes
Other Study ID Numbers: TB022
Study First Received: August 11, 2010
Last Updated: March 25, 2011
Health Authority: United Kingdom: Medicines and Healthcare Products Regulatory Agency

Keywords provided by University of Oxford:
Vaccine
MVA 85A

Additional relevant MeSH terms:
Tuberculosis
Actinomycetales Infections
Bacterial Infections
Gram-Positive Bacterial Infections
Mycobacterium Infections

ClinicalTrials.gov processed this record on November 20, 2014