A Dangerous Triad in Ageing and in Chronic Obstructive Pulmonary Disease (COPD) - Reduced Muscle Mass, Impaired Muscle Function and Malnutrition

This study has been completed.
Sponsor:
Collaborators:
The Swedish Research Council
The Swedish Heart and Lung Association
Swedish Heart Lung Foundation
Information provided by:
Göteborg University
ClinicalTrials.gov Identifier:
NCT01179178
First received: August 9, 2010
Last updated: August 10, 2010
Last verified: January 2006
  Purpose

The investigators have taken part in the development of simple muscle function tests and studied physical training and energy turnover in patients with chronic obstructive pulmonary disease, COPD. The investigators have found that muscle wasting in COPD is related to poor prognosis and that physical training might lead to improved, less energy-demanding muscle function. Elderly subjects also suffer from muscle wasting that leads to frailty, poor autonomy and, secondarily, fractures. In the planned study the investigators will validate simple muscle function tests (hand grip strength, heel rise test, voluntary quadriceps muscle strength, 30 m walking test and balance tests) in both groups by relating them to an involuntary, magnet stimulated, test of quadriceps force, HRQL, tests of body composition (impedance, DXA) and recordings of physical activity. The relation between food intake, systemic inflammation, muscle mass and function will be analysed.

The study has been ethically approved and started in COPD patients and will be expanded to a representative sample of elderly.

Simple, evaluated muscle function tests applied in primary care may be used for early detection of muscle dysfunction in COPD patients and elderly so that early intervention against impaired muscle function can be started. Analyses of food intake and of inflammatory markers might identify factors of special importance for muscle dysfunction, which eventually might lead to improved dietary therapy and pharmacological interventions.


Condition
Pulmonary Disease, Chronic Obstructive

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: A Dangerous Triad in Ageing and in COPD - Reduced Muscle Mass, Impaired Muscle Function and Malnutrition

Resource links provided by NLM:


Further study details as provided by Göteborg University:

Study Start Date: March 2006
Study Completion Date: December 2009
Primary Completion Date: December 2009 (Final data collection date for primary outcome measure)
Groups/Cohorts
COPD-patients
Older adults (65-81 y)

  Eligibility

Ages Eligible for Study:   65 Years to 81 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

Outpatients (COPD) and older adults living in Gothenburg

Criteria

Inclusion Criteria:

  • Women and men between 65 and 81 years of age, randomly selected from the national registration, are invited to take part in the study.
  • Patients referred to the outpatient clinic of the lung unit at Sahlgrenska University Hospital with a diagnosis of COPD are asked for participation.
  • Inclusion criteria for COPD patients:
  • Clinical diagnosis of COPD
  • FEV% < normal value minus 2 SD
  • Smoking history; 10 pack years or more

Exclusion Criteria:

  • Any specific muscular disease
  • Severe disease or handicap making investigations impossible
  • Exclusion criteria for COPD patients:
  • Any specific muscular disease
  • Any co-existing serious disease
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01179178

Locations
Sweden
Dept of Clinical Nutrition, Sahlgrenska Academy at University of Gothenburg
Göteborg, Sweden, 44232
Sponsors and Collaborators
Göteborg University
The Swedish Research Council
The Swedish Heart and Lung Association
Swedish Heart Lung Foundation
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT01179178     History of Changes
Other Study ID Numbers: UGOTTriad, Grant
Study First Received: August 9, 2010
Last Updated: August 10, 2010
Health Authority: Sweden: Regional Ethical Review Board

Additional relevant MeSH terms:
Lung Diseases
Lung Diseases, Obstructive
Pulmonary Disease, Chronic Obstructive
Malnutrition
Nutrition Disorders
Chronic Disease
Respiratory Tract Diseases
Disease Attributes
Pathologic Processes

ClinicalTrials.gov processed this record on October 16, 2014