Developmental Pathways to Metabolic Disease - Growing Up in Singapore Towards Healthy Outcomes (GUSTO)
Recruitment status was Recruiting
This study aims to test the following two hypotheses in women recruited in early pregnancy and whose children will be followed up till 3 years of age.
- Epigenetic changes in conceptual tissues obtained at birth reflect the environment that the foetus was exposed to during development.
- The pattern of epigenetic marks in gene promoters obtained from DNA in birth tissues, together with genotype, phenotype, and environmental exposures assessed early in life, can be utilized to predict growth trajectories that will lead to obesity and risk of metabolic disease.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Growing Up in Singapore Towards Healthy Outcomes|
- The pattern of epigenetic marks in birth tissues [ Time Frame: Perinatal ] [ Designated as safety issue: No ]To examine how epigenetic change at birth both reflects past developmental influences and, in association with other factors, influences future trajectories of development and its relationship to metabolic risk.
- Influence of prenatal factors [ Time Frame: During pregnancy and infancy period of the child ] [ Designated as safety issue: No ]The influence of prenatal factors as predictors of epigenetic variants, body composition at birth, and early postnatal growth
Biospecimen Retention: Samples With DNA
During pregnancy; Mother: blood, salival and hair samples. At delivery; cord, cord blood and placenta. During infancy; Stool, saliva and buccal samples from the children breast milk from breeastfeeding mothers
|Study Start Date:||June 2009|
|Estimated Study Completion Date:||September 2013|
|Estimated Primary Completion Date:||September 2013 (Final data collection date for primary outcome measure)|
Pregnant mothers, neonates and infants
Women in their early pregnancy who are attending the first trimester antenatal ultrasound scan at the public maternity units at KK Women's and Children's Hospital and National University Hospital. Only women age of 18 years and above who are Singapore Citizens or Singapore Permanent Residents. Participants have to intend to eventually deliver in NUH or KKH and to reside in Singapore for the next 5 years. Willingness to donate cord, cord blood and placenta. The fetus should be racially homogenous with both sets of grandparents of the same ethnicity. Babies born from these mothers will be followed up until the child is 3 years of age.
A center piece of this study is to examine how epigenetic change at birth both reflects past developmental influences and, in association with other factors, influences future trajectories of development and its relationship to metabolic risk. Several factors stand out - firstly, the recognition that visceral obesity can be present at birth and differ markedly between babies of different ethnicity 3; and secondly, that early measures of body composition may predict childhood obesity; and thirdly, that epigenetic changes in conceptual tissues in humans and in metabolically active tissues in rodents relate to later metabolic destiny.The unique features of the GUSTO study are that at birth, body composition will be assessed and epigenetic and genomic measures on umbilical cord DNA analysed in an Asian population. Few birth cohorts have included substantial proportions of subjects from different ethnic groups and the multiethnic focus of this study is unique. Inter-ethnic differences in epigenetic factors, body composition, 3 developmental and growth patterns in Chinese, Malays, and Indians will be contrasted. Chinese, Malays and Indians represent three of the major ethnic groups in Asia and previous studies have shown clear ethnic differences in metabolic risk profiles.7 Ethnic differences in body composition at birth, reported previously, suggest that ethnic differences in metabolic disease risk have developmental origins.The GUSTO study will provide a unique opportunity to investigate the developmental pathways leading to differing metabolic risk in these three ethnic groups. The influence of prenatal factors as predictors of epigenetic variants,body composition at birth, and early postnatal growth will be evaluated, while the impact of epigenetic variations on early obesity and infant growth, will be determined.
|Contact: Seang Mei Saw||6565164976|
|Contact: Yap Seng Chong||6567724272|
|National University Hospital||Recruiting|
|Contact: Janie Foo, BSc 6567724260|
|Contact: Shenzi Iris, M.D 6565164079|
|Principal Investigator: Yap Seng Chong|
|Principal Investigator:||Yap Seng Chong||National University Health System|