Examining Common Substrates of Eating and Alcohol Use Disorders

This study is currently recruiting participants. (see Contacts and Locations)
Verified April 2013 by New York State Psychiatric Institute
Sponsor:
Information provided by (Responsible Party):
New York State Psychiatric Institute
ClinicalTrials.gov Identifier:
NCT01172210
First received: July 28, 2010
Last updated: April 30, 2013
Last verified: April 2013
  Purpose

A substantial percentage of individuals with bulimia nervosa (BN) also meet criteria for a co-occurring substance use disorder, such as alcohol abuse or dependence; however, research examining this sub-group of patients with BN is limited. Understanding characteristics common to both eating and alcohol use disorders may enhance understanding of the mechanisms that could contribute to the co-occurrence and perpetuation of these disorders. Individuals with BN and alcohol use disorders appear to share some behavioral traits, and therefore, the primary aim of the current study is to compare patients with BN with and without an alcohol use disorder and normal controls on measures assessing an individual's mood and ability to perform certain tasks. Participants will be asked to complete computer-administered and paper-and-pencil assessments and two laboratory test meals on separate days. By probing the underpinnings of BN and alcohol use disorders, the investigators can determine whether these disorders have a shared diathesis, which will lay an essential foundation for future research to examine biological and genetic correlates of these disorders. Finally, as little is known about the treatment of patients with BN and a co-occurring alcohol use disorder, an exploratory aim of the current study is evaluate the suitability and efficacy of a 20-session cognitive-behavioral treatment (CBT) addressing both bulimic symptoms and alcohol use.


Condition
Bulimia Nervosa
Alcohol Use Disorders

Study Type: Observational
Official Title: Examining Common Substrates of Eating and Alcohol Use Disorders

Resource links provided by NLM:


Further study details as provided by New York State Psychiatric Institute:

Primary Outcome Measures:
  • Eating Behavior [ Time Frame: Baseline ] [ Designated as safety issue: No ]

Estimated Enrollment: 75
Study Start Date: July 2009
Estimated Study Completion Date: December 2013
Estimated Primary Completion Date: December 2013 (Final data collection date for primary outcome measure)
Groups/Cohorts
Bulimia Nervosa
Bulimia Nervosa w/ Alcohol Use Disorder
Healthy Controls

Detailed Description:

A substantial percentage of individuals with bulimia nervosa (BN) also meet criteria for a co-occurring substance use disorder, such as alcohol abuse or dependence; however, research examining this sub-group of patients with BN is limited. Understanding characteristics common to both eating and alcohol use disorders may enhance our understanding of the mechanisms that could contribute to the co-occurrence and perpetuation of these disorders. The primary aim of the current study is to compare patients with BN with and without an alcohol use disorder and normal controls on computer-administered and paper-and-pencil assessments and in two laboratory test meals (a binge meal and a normal meal) on separate days. Participants will also complete self-report and interview measures of eating disorder symptoms and alcohol consumption. By probing the underpinnings of BN and alcohol use disorders, we can determine whether these disorders have a shared diathesis, which will lay an essential foundation for future research to examine biological and genetic correlates of these disorders. Finally, as little is known about the treatment of patients with BN and a co occurring alcohol use disorder, an exploratory aim of the current study is to evaluate the suitability and efficacy of a 20-session cognitive-behavioral treatment (CBT) addressing both bulimic symptoms and alcohol use.

  Eligibility

Ages Eligible for Study:   18 Years to 45 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Participants who call the main clinic line at the Eating Disorders Research Unit at NYSPI/CUMC.

Criteria

Inclusion Criteria:

  • Age 18-45
  • Diagnosis of bulimia nervosa with or without a co-occurring alcohol use disorder
  • English speaking
  • Weight above 80% of ideal

Exclusion Criteria:

  • Other significant psychiatric conditions requiring treatment or a significant medical condition
  • Pregnancy
  • Current use of psychotropic medication
  • History of neurological disorder (e.g., dementia, stroke seizure)
  • Food allergy to items in the lunch buffet
  • Positive urine drug screen
  • Current or post eating disorder diagnosis or history of binge eating or vomiting
  • Current or past alcohol or substance abuse or dependence
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01172210

Contacts
Contact: Simona Kaplan, BA 212-543-5739

Locations
United States, New York
New York State Psychiatric Institute Recruiting
New York, New York, United States, 10032
Contact: Robyn Sysko, Ph.D.    212-543-5739      
New York State Psychiatric Institute Recruiting
New York, New York, United States, 10032
Principal Investigator: Robyn Sysko, PhD         
Sponsors and Collaborators
New York State Psychiatric Institute
Investigators
Principal Investigator: Robyn Sysko, Ph.D. New York State Psychiatric Institute
  More Information

Additional Information:
No publications provided

Responsible Party: New York State Psychiatric Institute
ClinicalTrials.gov Identifier: NCT01172210     History of Changes
Other Study ID Numbers: 5973
Study First Received: July 28, 2010
Last Updated: April 30, 2013
Health Authority: United States: Institutional Review Board

Additional relevant MeSH terms:
Alcohol Drinking
Bulimia
Bulimia Nervosa
Drinking Behavior
Hyperphagia
Signs and Symptoms, Digestive
Signs and Symptoms
Eating Disorders
Mental Disorders

ClinicalTrials.gov processed this record on July 26, 2014