Examining Common Substrates of Eating and Alcohol Use Disorders
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Purpose
A substantial percentage of individuals with bulimia nervosa (BN) also meet criteria for a co-occurring substance use disorder, such as alcohol abuse or dependence; however, research examining this sub-group of patients with BN is limited. Understanding characteristics common to both eating and alcohol use disorders may enhance understanding of the mechanisms that could contribute to the co-occurrence and perpetuation of these disorders. Individuals with BN and alcohol use disorders appear to share some behavioral traits, and therefore, the primary aim of the current study is to compare patients with BN with and without an alcohol use disorder and normal controls on measures assessing an individual's mood and ability to perform certain tasks. Participants will be asked to complete computer-administered and paper-and-pencil assessments and two laboratory test meals on separate days. By probing the underpinnings of BN and alcohol use disorders, the investigators can determine whether these disorders have a shared diathesis, which will lay an essential foundation for future research to examine biological and genetic correlates of these disorders. Finally, as little is known about the treatment of patients with BN and a co-occurring alcohol use disorder, an exploratory aim of the current study is evaluate the suitability and efficacy of a 20-session cognitive-behavioral treatment (CBT) addressing both bulimic symptoms and alcohol use.
| Condition |
|---|
|
Bulimia Nervosa Alcohol Use Disorders |
| Study Type: | Observational |
| Official Title: | Examining Common Substrates of Eating and Alcohol Use Disorders |
- Eating Behavior [ Time Frame: Baseline ] [ Designated as safety issue: No ]
| Estimated Enrollment: | 75 |
| Study Start Date: | July 2009 |
| Estimated Study Completion Date: | December 2013 |
| Estimated Primary Completion Date: | December 2013 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
|---|
| Bulimia Nervosa |
| Bulimia Nervosa w/ Alcohol Use Disorder |
| Healthy Controls |
Detailed Description:
A substantial percentage of individuals with bulimia nervosa (BN) also meet criteria for a co-occurring substance use disorder, such as alcohol abuse or dependence; however, research examining this sub-group of patients with BN is limited. Understanding characteristics common to both eating and alcohol use disorders may enhance our understanding of the mechanisms that could contribute to the co-occurrence and perpetuation of these disorders. The primary aim of the current study is to compare patients with BN with and without an alcohol use disorder and normal controls on computer-administered and paper-and-pencil assessments and in two laboratory test meals (a binge meal and a normal meal) on separate days. Participants will also complete self-report and interview measures of eating disorder symptoms and alcohol consumption. By probing the underpinnings of BN and alcohol use disorders, we can determine whether these disorders have a shared diathesis, which will lay an essential foundation for future research to examine biological and genetic correlates of these disorders. Finally, as little is known about the treatment of patients with BN and a co occurring alcohol use disorder, an exploratory aim of the current study is to evaluate the suitability and efficacy of a 20-session cognitive-behavioral treatment (CBT) addressing both bulimic symptoms and alcohol use.
Eligibility| Ages Eligible for Study: | 18 Years to 45 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
Participants who call the main clinic line at the Eating Disorders Research Unit at NYSPI/CUMC.
Inclusion Criteria:
- Age 18-45
- Diagnosis of bulimia nervosa with or without a co-occurring alcohol use disorder
- English speaking
- Weight above 80% of ideal
Exclusion Criteria:
- Other significant psychiatric conditions requiring treatment or a significant medical condition
- Pregnancy
- Current use of psychotropic medication
- History of neurological disorder (e.g., dementia, stroke seizure)
- Food allergy to items in the lunch buffet
- Positive urine drug screen
- Current or post eating disorder diagnosis or history of binge eating or vomiting
- Current or past alcohol or substance abuse or dependence
Contacts and Locations| Contact: Simona Kaplan, BA | 212-543-5739 |
| United States, New York | |
| New York State Psychiatric Institute | Recruiting |
| New York, New York, United States, 10032 | |
| Contact: Robyn Sysko, Ph.D. 212-543-5739 | |
| New York State Psychiatric Institute | Recruiting |
| New York, New York, United States, 10032 | |
| Principal Investigator: Robyn Sysko, PhD | |
| Principal Investigator: | Robyn Sysko, Ph.D. | New York State Psychiatric Institute |
More Information
Additional Information:
No publications provided
| Responsible Party: | New York State Psychiatric Institute |
| ClinicalTrials.gov Identifier: | NCT01172210 History of Changes |
| Other Study ID Numbers: | 5973 |
| Study First Received: | July 28, 2010 |
| Last Updated: | April 30, 2013 |
| Health Authority: | United States: Institutional Review Board |
Additional relevant MeSH terms:
|
Alcohol Drinking Bulimia Bulimia Nervosa Drinking Behavior Hyperphagia |
Signs and Symptoms, Digestive Signs and Symptoms Eating Disorders Mental Disorders |
ClinicalTrials.gov processed this record on May 23, 2013