The Rate of C-reactive Protein (CRP) Increase as a Marker for Bacterial Infections in Children (CRPv)
Recruitment status was Not yet recruiting
Fever is one of the most common problems in pediatrics. Differentiating between bacterial infections, that require antibiotic therapy, and viral infections that resolve on their own is an important challenge for physicians.
C-reactive protein (CRP) is a protein that increases in response to inflammation and its level is generally higher in bacterial infections compared to viral infections. it can be measured by a simple blood test, however its utility as a sole marker for bacterial infection is limited.
The hypothesis of the study is that measuring CRP velocity, e.g the value of CRP divided by the hours since the fever started will improve the utility of CRP for the diagnosis of bacterial infections in children.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||CRP Velocity as a Marker for Bacterial Infections in Children|
|Study Start Date:||September 2010|
|Estimated Study Completion Date:||September 2011|
|Estimated Primary Completion Date:||September 2011 (Final data collection date for primary outcome measure)|
children with fever due to bacterial infection
children with fever due to viral infection