Potential Beneficial Effects of Resveratrol
We want to investigate whether the food supplement resveratrol is able to counteract the detrimental effects of obesity.
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Caregiver, Investigator)
Primary Purpose: Basic Science
|Official Title:||Potential Beneficial Effects of Resveratrol on Obesity, Metabolic Syndrome and Inflammation - Emphasis on Description of the Molecular Biology Underpinning the Interplay Between Calorie Restriction, SIRT1, STAT5 and the GH/IGF-I Axis|
- Metabolic parameters [ Time Frame: Five weeks ] [ Designated as safety issue: No ]Regarding glucose, protein and fat metabolism.
- Pathways of substrate metabolism. [ Time Frame: Five weeks ] [ Designated as safety issue: No ]Description of the biochemical pathways underpinning the interplay between calorie restriction, SIRT1, STAT5 and the GH/IGF-I axis.
|Study Start Date:||October 2010|
|Study Completion Date:||November 2011|
|Primary Completion Date:||November 2011 (Final data collection date for primary outcome measure)|
Active Comparator: Resveratrol
Dietary supplement of resveratrol 500 mg three times a day over five weeks.
Dietary Supplement: Resveratrol
500 mg three times a day for five weeks.
Other Name: Fluxome Sciences.
|Placebo Comparator: Placebo||
Placebo (starch capsules) 500 mg three times a day for five weeks.
Other Name: Starch
The aim of this study is to investigate potential metabolic effects of resveratrol in healthy but obese men. We hypothesize that resveratrol will counteract some of the detrimental effects of obesity, and as an imitator of calorie restriction will give new insight into the basic biochemical pathways underpinning human metabolism. Of special interest is the potential connection between resveratrol, calorie restriction, SIRT1, STAT5b and the GH/IGF-I axis.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01150955
|Aarhus University Hospital, Department of Endocrinology, MEA|
|Aarhus, Denmark, 8000|
|Study Chair:||Jens Otto L Jørgensen, Professor,MD||Aarhus University Hospital|