Trial record 1 of 1 for:    ocdc
Previous Study | Return to List | Next Study

Autologous OC-DC Vaccine in Ovarian Cancer

This study is currently recruiting participants. (see Contacts and Locations)
Verified August 2012 by Abramson Cancer Center of the University of Pennsylvania
Sponsor:
Information provided by (Responsible Party):
Abramson Cancer Center of the University of Pennsylvania
ClinicalTrials.gov Identifier:
NCT01132014
First received: May 26, 2010
Last updated: August 6, 2012
Last verified: August 2012
  Purpose

This is a three cohort sequential clinical trial for subjects with recurrent ovarian, fallopian tube or primary peritoneal cancer to determine the feasibility and safety as well as immunogenicity of OC-DC, an autologous vaccine comprised of autologous dendritic cells (DC) loaded in vitro with lysate from autologous oxidized tumor cells, administered intranodally alone or in combination with intravenous Bevacizumab and Cyclophosphamide.


Condition Intervention Phase
Chemotherapy
Tumor
Ovarian Cancer
Biological: OCDC
Phase 0

Study Type: Interventional
Study Design: Endpoint Classification: Safety Study
Primary Purpose: Treatment
Official Title: A Pilot Clinical Trial of Dendritic Cell Vaccine Loaded With Autologous Tumor for Recurrent Ovarian, Primary Peritoneal or Fallopian Tube Cancer

Resource links provided by NLM:


Further study details as provided by Abramson Cancer Center of the University of Pennsylvania:

Primary Outcome Measures:
  • Safety [ Time Frame: 30 days of last vaccination ] [ Designated as safety issue: Yes ]
    Safety will be established by grading the observed toxicities using the NCI Common Toxicity Criteria (CTC Version3.0). All toxicities observed within 30 days of last vaccination will be included.


Secondary Outcome Measures:
  • Clinical Response [ Designated as safety issue: Yes ]
    Clinical Response will be determined by RECIST criteria. Response rate is the proportion of patients that achieve CR or PR.

  • Dose limiting toxicity [ Designated as safety issue: Yes ]
    Dose-limiting toxicity is defined as: any Grade 3 or higher allergic, autoimmune or injection site reaction or any Grade 4 hematologic or non-hematologic toxicity (except fever).

  • Immune Response Immune Response [ Designated as safety issue: Yes ]
    Immune response will be evaluated by IFN-g ELISPOT analysis of tumor-reactive T cells, and in HLAA2+ subjects, by tetramer analysis of Her-2 specific T cells in peripheral blood. Response is defined by a 3 fold increase relative to pre-vaccination.


Estimated Enrollment: 15
Study Start Date: May 2010
Estimated Study Completion Date: May 2015
Estimated Primary Completion Date: May 2015 (Final data collection date for primary outcome measure)
Intervention Details:
    Biological: OCDC
    OCDC,an autologous vaccine comprised of autologous dendritic cells (DC) loaded in vitro with lysate from autologous oxidized tumor cells, administered intranodally alone, or in combination with either intravenous Daclizumab, or with a combination of Daclizumab and intravenous Bevacizumab.
  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria

  • Subject has had prior cytoreductive surgery yielding tumor for lysate preparation.
  • Lysate must meet release criteria
  • Subject is 18 years of age or older.
  • Subject has an ECOG performance status of less than 1.
  • Subject has a life expectancy of greater than 6 months.
  • Subject must understand and sign the study specific informed consent.
  • Subject may have received chemotherapy or other therapy after harvest of tumor and prior to enrollment. Subjects who have achieved complete response following chemotherapy are still eligible for participation
  • Subject is platinum-sensitive (progression-free interval greater than 6 months prior to recent recurrence) or platinum-resistant (progression-free interval less than 6 months prior to recent recurrence).
  • Subject has recovered from toxicities of prior chemotherapy or other therapy (to grade 2 or less).
  • Subject may have received prior investigational therapy (including immune therapy).
  • Subject may have received prior hormonal therapy.
  • Subject may have received prior radiation therapy (except to inguinal region) but must have completed such therapy prior to enrollment.
  • Subject has had at least 4 weeks of postoperative recovery from surgery prior to enrollment to ensure complete wound healing. Subjects with bowel resections at surgery who enroll in cohort 2 will begin protocol at least 42 days after surgery if debulking surgery had comprised of bowel resection or other bowel surgery.
  • Subjects who screen fails can be re-enrolled if the causation of the screen fail has been corrected.

Exclusion Criteria

  • Subject for whom tumor lysate does not meet release criteria
  • Subject has a positive serum Yo antibody
  • Subject whose groins are not accessible.
  • Subject has a chronic or acute hepatitis C infection.
  • Subject has a chronic or acute hepatitis B infection.
  • Subject has positive test result at the screening visit for one or more of the following:
  • HTLV-1/2
  • Anti-HIV 1 Antibody (-HIV-1)
  • Subject requires or is likely to require more than a two-week course of corticosteroids for intercurrent illness. Subject must complete the course of corticosteroids 2 weeks before screening to meet eligibility.
  • Subject has renal insufficiency as defined by a serum creatinine greater than 2.2 mg/dl or BUN greater than 40 mg/dl. Note: If creatinine is greater than 1.5 x ULN, creatinine clearance must be greater than 60ml/min.
  • Subject has proteinuria greater than 3.5 gm over 24 hrs are not eligible for the study (cohort 2 only)
  • Subject with liver failure as defined by a serum total bilirubin greater than 2.0 and/or serum transaminases greater than 3X the upper limits of normal.
  • Subject has hematopoietic failure at baseline as defined by one of the following:
  • Platelets less than 100,000/ mm3
  • WBC less than 2,500/mm3
  • Absolute Neutrophil Count (ANC) less than 1,000/mm3
  • Absolute lymphocyte count less than 200/ mm3
  • Hematocrit less than 30%
  • Subject has any acute infection that requires specific therapy. Acute therapy must have been completed within seven days prior to study enrollment.
  • Subject has a serious, non-healing wound, ulcer, or bone fracture.
  • Subject has a clinically significant cardiovascular disease including:
  • Uncontrolled hypertension;
  • Myocardial infarction or unstable angina within 6 months prior to enrollment
  • New York Heart Association (NYHA) Grade II or greater congestive heart failure
  • Subject has a grade II or greater peripheral vascular disease.
  • Subject has a clinically significant peripheral artery disease, e.g., those with claudication, within 6 months.
  • Subject has any underlying conditions, which would contraindicate therapy with study treatment (or allergies to reagents used in this study).
  • Subject has organ allografts.
  • Subject is receiving medication(s) that might affect immune function. Use of H2 antagonists are prohibited as are all antihistamines five days before and five days after each injection of study vaccine. However, NSAIDS including COX-2 inhibitors, acetaminophen or aspirin are permitted.
  • Subject has clinical symptoms or signs of partial or complete gastrointestinal obstruction or who require parenteral hydration and/or nutrition (For cohort 2 and cohort 3).
  • Subjects with a History of bowel obstruction, including sub-occlusive disease, related to the underlying disease and history of abdominal fistula, gastrointestinal perforation or intra-abdominal abscess.
  • Subjects with evidence of recto-sigmoid involvement by pelvic examination or bowel involvement on CT scan or clinical symptoms of bowel obstruction.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01132014

Contacts
Contact: Clinical Team 215-615-7447 OCRC.Trials@uphs.upenn.edu

Locations
United States, Pennsylvania
Abramson Cancer Center of the University of Pennsylvania Recruiting
Philadelphia, Pennsylvania, United States, 19104
Contact: Clinical Team    215-615-7447    OCRC.Trials@uphs.upenn.edu   
Principal Investigator: Janos Tanyi, MD         
Sponsors and Collaborators
Abramson Cancer Center of the University of Pennsylvania
Investigators
Principal Investigator: Janos Tanyi, MD Abramson Cancer Center of the University of Pennsylvania
  More Information

No publications provided by Abramson Cancer Center of the University of Pennsylvania

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Abramson Cancer Center of the University of Pennsylvania
ClinicalTrials.gov Identifier: NCT01132014     History of Changes
Other Study ID Numbers: UPCC 19809
Study First Received: May 26, 2010
Last Updated: August 6, 2012
Health Authority: United States: Food and Drug Administration

Keywords provided by Abramson Cancer Center of the University of Pennsylvania:
Subjects with recurrent ovarian, fallopian tube or primary peritoneal cancer,
from whom solid tumor or ascites have been harvested and are available and
sufficient for tumorlysate preparation;and whose largest tumor nodule is 4.5
cm. Subjects may have undergone chemotherapy or other therapy following
tumor harvesting and prior to enrollment.

Additional relevant MeSH terms:
Ovarian Neoplasms
Fallopian Tube Neoplasms
Endocrine Gland Neoplasms
Neoplasms by Site
Neoplasms
Ovarian Diseases
Adnexal Diseases
Genital Diseases, Female
Genital Neoplasms, Female
Urogenital Neoplasms
Endocrine System Diseases
Gonadal Disorders
Fallopian Tube Diseases

ClinicalTrials.gov processed this record on August 21, 2014