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Role of CCL2 in Alcoholic Liver Diseases

This study has been completed.
Sponsor:
Information provided by:
Erasme University Hospital
ClinicalTrials.gov Identifier:
NCT01128010
First received: May 20, 2010
Last updated: NA
Last verified: December 2002
History: No changes posted
  Purpose

Immune dysregulations, including cytokines and chemokines secretions occurs in alcoholic liver disease. Serum levels and liver expression of CCL2 are increased in patients with alcoholic hepatitis but the role of this chemokine in the pathogenesis of alcoholic liver disease is nevertheless unknown. The aim of the study is to analyze plasma level and liver expression of CCL2 and their relation with liver disease severity and inflammatory infiltrate in our cohort of alcoholic patients. We studied also the association between -2518 CCL2 polymorphism and the severity of alcoholic liver disease.


Condition
Alcoholic Liver Disease

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective

Resource links provided by NLM:

MedlinePlus related topics: Liver Diseases
U.S. FDA Resources

Further study details as provided by Erasme University Hospital:

Groups/Cohorts
alcoholic liver disease
alcoholic liver disease patients undergoing a transjugular liver biopsy in our institution
controls
Healthy controls patients recruited from the Occupational Medicine Department during a routine physical examination

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

Consecutive patients undergoing transjugular liver biopsy for alcoholic liver disease will be include in the study to measure plasma levels and hepatic expression of CCL2. We determine also the rs1024611 polymorphism of these patients. All these parameters are correlated to severity of the disease.

The frequency of the presence of this polymorphism was also compared to a population of healthy subjects.

Criteria

ALD patients

Inclusion Criteria:

  • Excess alcohol intake
  • Abnormality of liver biopsy compatible with alcoholic aetiology
  • Caucasian ethnicity

Exclusion Criteria:

  • Presence of any other chronic liver disease
  • co-infection with HIV Controls Inclusion criteria
  • Caucasian ethnicity
  • presence of a disease
  Contacts and Locations
No Contacts or Locations Provided
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT01128010     History of Changes
Other Study ID Numbers: DD-CCL2
Study First Received: May 20, 2010
Last Updated: May 20, 2010
Health Authority: Belgium: Ethics Committee

Additional relevant MeSH terms:
Liver Diseases
Liver Diseases, Alcoholic
Digestive System Diseases
 Alcohol-Induced Disorders
Alcohol-Related Disorders
Substance-Related Disorders

ClinicalTrials.gov processed this record on June 18, 2013