Local Effects of Epinephrine on Lactate, Glucose, Lipid and Protein Metabolism in Bilaterally Perfused Human Legs

This study has been completed.
Sponsor:
Information provided by (Responsible Party):
University of Aarhus
ClinicalTrials.gov Identifier:
NCT01116609
First received: April 9, 2010
Last updated: November 4, 2011
Last verified: November 2011
  Purpose

The purpose of this study is to define the local metabolic effects of epinephrine in the bilaterally perfused human leg.


Condition Intervention
Healthy
Drug: Epinephrine

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Single Blind (Subject)
Primary Purpose: Basic Science
Official Title: Local Effects of Epinephrine on Lactate, Glucose, Lipid and Protein Metabolism in Bilaterally Perfused Human Legs

Resource links provided by NLM:


Further study details as provided by University of Aarhus:

Primary Outcome Measures:
  • Arterio-Venous balances of metabolites [ Time Frame: 6 hours infusion ] [ Designated as safety issue: No ]
    Acute regional effect of epinephrine infusion in the femoral artery


Enrollment: 10
Study Start Date: October 2004
Study Completion Date: January 2010
Primary Completion Date: November 2009 (Final data collection date for primary outcome measure)
Intervention Details:
    Drug: Epinephrine
    unilateral leg infusion of Epinephrine 0.4 micrograms/m2/min
    Other Name: Adrenaline
  Eligibility

Ages Eligible for Study:   18 Years to 50 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Male

Exclusion Criteria:

  • Comorbidity
  • Females
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01116609

Locations
Denmark
Medical research laboratories, Aarhus University Hospital
Aarhus, Denmark, 8000
Sponsors and Collaborators
University of Aarhus
Investigators
Principal Investigator: Niels Moller, Professor Medical Research Laboratories, Aarhus University, Denmark
  More Information

No publications provided

Responsible Party: University of Aarhus
ClinicalTrials.gov Identifier: NCT01116609     History of Changes
Other Study ID Numbers: Epi-perfusion
Study First Received: April 9, 2010
Last Updated: November 4, 2011
Health Authority: Denmark: The Regional Committee on Biomedical Research Ethics

Keywords provided by University of Aarhus:
Phenylalanine
Palmitate
hyperinsulinemic-euglycemic-clamp
Effects of epinephrine in healthy volunteers

Additional relevant MeSH terms:
Epinephrine
Racepinephrine
Epinephryl borate
Adrenergic alpha-Agonists
Adrenergic Agonists
Adrenergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Pharmacologic Actions
Physiological Effects of Drugs
Adrenergic beta-Agonists
Bronchodilator Agents
Autonomic Agents
Peripheral Nervous System Agents
Anti-Asthmatic Agents
Respiratory System Agents
Therapeutic Uses
Mydriatics
Sympathomimetics
Vasoconstrictor Agents
Cardiovascular Agents

ClinicalTrials.gov processed this record on August 26, 2014