Trial record 4 of 88 for:
Open Studies | "Aortic Aneurysm, Abdominal"
Non Invasive Imaging of Abdominal Aorta Aneurysm Hemodynamics and Wall Structure
The recruitment status of this study is unknown because the information has not been verified recently.
Verified January 2012 by Aarhus University Hospital.
Recruitment status was Recruiting
Information provided by (Responsible Party):
Nikolaj Eldrup, Aarhus University Hospital
First received: April 14, 2010
Last updated: January 18, 2012
Last verified: January 2012
The development of the abdominal aorta aneurysm is multifactorial. Through use of magnetic resonance imaging without contrast, this study will look closely at flow, the stresses hereby induced, as well as signs of inflammation in the vessel wall.
Aortic Aneurysm, Abdominal
||Time Perspective: Cross-Sectional
||Non Invasive in Vivo Evaluation of Abdominal Aorta Aneurysm Hemodynamics, Wall Stress, and Inflammation Using Magnetic Resonance Imaging
| Estimated Enrollment:
| Study Start Date:
| Estimated Study Completion Date:
| Estimated Primary Completion Date:
||March 2012 (Final data collection date for primary outcome measure)
The etiology of the abdominal aorta aneurysm is complex and multi-factorial. Biomechanic and hemodynamic stress contributes to aneurysmal growth, and the relevance of inflammation is gaining in terms of pathological influence. The technical advances of imaging now enable one to utilize magnetic resonance in reconstructing aortal blood flow. Newer post-imaging software then enables one to perform complex data analysis, wherein shear and wall-stress can be calculated. The goal of this study is to analyze the aneurysms of twenty patients. Values will be obtained for shear and wall stress. Additionally, the utilization of short tau wave inversion recovery (STIR) sequences will be performed to evaluate the presence or absence of acute edema and inflammation of the region. It should also be noted that particular attention will be placed on the so-called "neck" of the aneurysm, where the aneurysm typically tapers into what is often regarded as normal aortic tissue. This region is important for both the placement of a surgical bypass prosthesis or a deployed stent graft.
|Ages Eligible for Study:
||20 Years to 90 Years
|Genders Eligible for Study:
|Accepts Healthy Volunteers:
Twenty patients diagnosed with an infrarenal abdominal aorta aneurysm will be selected from our clinical database.
- Infrarenal abdominal aorta aneurysm (AAA)
- Lack of signed, informed consent
- Pacemaker or other implanted metal prostheses
- Diabetes Mellitus
- Thoracoabdominal aorta aneurysm, per Crawford/Safi criteria
- Ehlers-Danlos, Marfans, or other diagnosed connective tissue disease
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study.
To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below.
For general information, see Learn About Clinical Studies.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01104688
|Contact: Jacob W Budtz-Lilly, MD
|Contact: William Paaske, Professor
|Aarhus University, Skejby Hospital, Department of cardiothoracic and vascular surgery & MR-center
|Aarhus, Denmark, 8000 |
|Contact (45) 89496990 |
Aarhus University Hospital
||Jacob W Budtz-Lilly, MD
||Aarhus University Hospital Skejby, Department of cardiothoracic and vascular surgery
No publications provided
||Nikolaj Eldrup, Counsultant MD PhD, Aarhus University Hospital
History of Changes
|Other Study ID Numbers:
|Study First Received:
||April 14, 2010
||January 18, 2012
||Denmark: The Regional Committee on Biomedical Research Ethics
Keywords provided by Aarhus University Hospital:
Abdominal Aortic Aneurysm
Magnetic Resonance Imaging
Additional relevant MeSH terms:
ClinicalTrials.gov processed this record on September 18, 2014
Aortic Aneurysm, Abdominal