Evaluation of Oxidative Stress and Effect of Levothyroxine Treatment on Oxidative Stress in Hashimoto Disease
Oxidative stress leads to or accompanies with numerous disease. Oxidative balance in subclinical hypothyroid or euthyroid state in Hashimoto disease are not known. Effect of levothyroxine therapy on oxidative balance are also not known in hashimoto disease.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Evaluation of Oxidative Stress and Effect of Levothyroxine Treatment on Oxidative Stress in Hashimoto Disease|
- Poxidative stress markers [ Time Frame: After levotren therapy ] [ Designated as safety issue: No ]...
Biospecimen Retention: Samples Without DNA
after overnight fasting state,venous blood will be taken to obtain serum.speciemens stored -70 cantigrade celcius untillanalysing.
|Study Start Date:||April 2010|
|Study Completion Date:||October 2010|
|Primary Completion Date:||April 2010 (Final data collection date for primary outcome measure)|
oxidative stress markers will be measured initially(TAS,TOS,OSI,PARAOXONASE,ARYLESTERASA,PON1 PHENOTYPİNG,LİPİDPEROXİD).After 3 months therapy with levothyroxine measurements will be repeated except PON1 phenotyping.
|Vakif Gureba Training and Research Hospital|
|Istanbul, Turkey, 34100|
|Study Chair:||Mehmet ali Cikrikcioglu, MD||vakif gureba TRH,fatih,istanbul,turkey.specialist in internal medicine|