Elastography in Thyroid Nodules
Nodular goiter is a highly prevalent disease in iodine-deficient areas. Usually nodule assessment includes ultrasonography (US) and fine-needle aspiration (FNA), but some benign nodules can hardly be distinguished from carcinomas. Elastography measures tissue elasticity using sonography, as malignancy is related to stiffness of solid organs. The investigators have designed a study to evaluate the diagnostic accuracy of elastography in nodular goiter. Consecutive patients will be assessed using US, FNA and elastography; the latter will be compared with cytology. Specificity, sensitivity, and predictive values will be calculated.
|Study Design:||Observational Model: Case Control
Time Perspective: Cross-Sectional
|Official Title:||Accuracy of Ultrasound Elastastography in Thyroid Nodular Disease.|
- Diagnostic accuracy of elastography for thyroid cancer [ Time Frame: 1 day ] [ Designated as safety issue: No ]Sensitivity, specifity, predictive values
Biospecimen Retention: Samples Without DNA
|Study Start Date:||February 2010|
|Study Completion Date:||September 2010|
|Primary Completion Date:||September 2010 (Final data collection date for primary outcome measure)|
Patients with nodular goiter
Performance of US, elastography and FNA.
Primary aim: to evaluate the diagnostic accuracy of elastography in thyroid nodules from a low-risk of thyroid cancer population.
Secondary aim: to evaluate the usefulness of elastography to detect carcinomas in thyroid nodules with indeterminate FNA.
- Age > 18 yr.
- Recruitment in Endocrinology Clinics.
- Nodular goiter.
- Multinodular goiter with dominant nodule > 1 cm.
- Toxic nodules
- Non-accessible nodules to US or FNA
- Cystic nodules
- Nodules with calcifications in egg rind
- Contraindication for FNA
Please refer to this study by its ClinicalTrials.gov identifier: NCT01102127
|Complejo Asistencial de León|
|León, Spain, 24008|
|Principal Investigator:||Alfonso Vidal-Casariego, MD||Complejo Asistencial de León|