Gene Expression Profiles in Healing and Non-Healing Wound (WHGS1)
The purpose of the research is to determine whether there are similar patterns of genes being turned on and/or turned off among people with healing and non-healing wounds.
Wounds and Injuries
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||Gene Expression Profiles in Healing and Non-Healing Wound.|
- Gene expression profiles [ Time Frame: 12 weeks ] [ Designated as safety issue: No ]determined using gene chip. This yields data in the form of relative rates of gene expression.
- Gene chip findings. [ Time Frame: 1 year or more. ] [ Designated as safety issue: No ]Gene chip findings healing verses non healing wounds.
Biospecimen Retention: Samples With DNA
|Study Start Date:||December 2004|
|Estimated Study Completion Date:||December 2020|
|Estimated Primary Completion Date:||December 2020 (Final data collection date for primary outcome measure)|
Healing verses non-healing
A single subject will provide 2 tissue samples from a single wound over a 4 week time period and the samples will be categorized as healing versus non-healing responses on the basis of decreased (healing) or increased (non-healing) wound area measurements over the 4-week time period. A chronic wound generally is a wound which shows no signs of significant healing in four weeks or has not healed in eight weeks.
|Contact: Urmila S Gnyawali, RNfirstname.lastname@example.org|
|United States, Ohio|
|Comprehensive Wound Center, The Ohio State University Medical Center.||Recruiting|
|Columbus, Ohio, United States, 43221|
|Contact: Urmila Gnyawali, RN 614-366-3515 email@example.com|
|Principal Investigator: Gayle Gordillo, MD|
|Sub-Investigator: Chandan Sen, PhD|
|Principal Investigator:||Gayle Gordillo, MD||Ohio State University|